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. 2023 Nov 24;27(4):682-688.
doi: 10.5935/1518-0557.20230065.

Abdominal Obesity May Play a Significant Role in inflammation Exacerbation in Polycystic Ovary Syndrome Patients

Fatemeh Shirvanizadeh  1 , Akram Eidi  1 , Maryam Hafezi  2 , Poopak Eftekhari-Yazdi  3
Affiliations

Abdominal Obesity May Play a Significant Role in inflammation Exacerbation in Polycystic Ovary Syndrome Patients

Fatemeh Shirvanizadeh et al. JBRA Assist Reprod. .

Abstract

Objective: Polycystic ovary syndrome (PCOS) is an endocrine disorder that seems to be pro-inflammatory at many levels, abdominal obesity (AO) is a prevalent pro-inflammatory phenotype in PCOS patients, and it seems to contribute to the initiation or worsening of inflammation in PCOS patients. In this study, we investigated the role of the AO phenotype in the occurrence of other obesity indicators (neck and arm) and augmentation of inflammation in the follicular fluid (FF) of PCOS patients.

Methods: 40 patients under the age of 35 were divided into four groups: PCOS with AO, PCOS without AO, non-PCOS with AO, and non-PCOS without AO. The FF samples were collected from each patient. Clinical and anthropometric characteristics of the participants, as well as tumor necrosis factor-α (TNF-α) concentration in the FF samples, were quantitatively assessed using enzyme-linked immunosorbent assays. The number of retrieved cumulus-oocyte complexes (COC) and their quality were scored.

Results: The PCOS+AO+ group had significantly increased neck circumference, compared to the other groups (p<0.001). The concentration of TNF-α was significantly higher in the PCOS+AO+ group than in the other groups (p<0.001). There were no significant differences in the number of retrieved COC per patient and the quality of oocytes between the groups (p>0.05).

Conclusions: Given the significant role of inflammation in the development of PCOS, managing AO in PCOS patients may aid in reducing inflammation and could potentially help in the design of customized treatment approaches.

Keywords: abdominal obesity; inflammation; polycystic ovary syndrome; tumor necrosis factor-α.

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Figures

Figure 1
Figure 1
The concentration of TNF-α in follicular fluid in four groups was measured by ELISA Data are mean ± SEM; n=10 per group; *p<0.05, **p<0.01, ****p<0.0001 were considered statistically significant.
Figure 2
Figure 2
The schematic illustration of the association between AO and inflammation in PCOS patients in decreasing fertility potential.
See this image and copyright information in PMC

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