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Randomized Controlled Trial
. 2024 Jan 3;111(1):znad357.
doi: 10.1093/bjs/znad357.

Effect of volatile versus total intravenous anaesthesia on circulating tumour cells after pancreatic adenocarcinoma resection: multicentre randomized clinical trial

Martin Schläpfer  1   2 , Erik Schadde  2   3   4 , Julia Braun  5 , Christopher Soll  4 , Stefan Breitenstein  4 , Markus Weber  6 , Stefan Gutknecht  6 , Michael T Ganter  7 , Miodrag Filipovic  8 , Beatrice Beck-Schimmer  1   2
Affiliations
Randomized Controlled Trial

Effect of volatile versus total intravenous anaesthesia on circulating tumour cells after pancreatic adenocarcinoma resection: multicentre randomized clinical trial

Martin Schläpfer et al. Br J Surg. .
No abstract available

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Conflict of interest statement

Conflict of interest B.B.S. has a patent (04/10/14–20140100278): Injectable formulation for treatment and protection of patients having an inflammatory reaction or an ischemia–reperfusion event; M. Urner, L. K. Limbach, I. K. Herrmann, W. J. Stark, B. Beck-Schimmer, applied as Patent Cooperation Treaty (internationally), July 2009, as well as a patent application on bioconjugates of antibodies and functionalized magnetic nanoparticles. B.B.S. and M.S. received grant money from Sedana Medical (Danderyd, Sweden) as collaborators in a large multicentre study not related to this topic. M.S. and B.B.S. received grant money from Roche Diagnostics International (Rotkreuz, Switzerland) for a clinical trial not related to this topic. The authors declare no other conflict of interest.

Figures

Fig. 1
Fig. 1
Analysis of maximum circulating tumour cell levels a Distribution of maximum circulating tumour cell (CTC) levels in the two treatment groups; bold lines represent median values. b Results of negative binomial regression models considering the confounders group allocation, baseline CTC more than 1 per 7.5 ml blood, microvascular invasion, lymph node (N) status, and resection (R1/R2). Incidence risk ratios are shown with 95 per cent confidence intervals.
Fig. 2
Fig. 2
Analysis of recurrence and survival a Kaplan–Meier plot showing probability of non-recurrence in desflurance and propofol groups (P = 0.589, log rank test). b Cox regression model for time to recurrence, including the confounders group allocation, microvascular invasion, lymph node (N) status, and resection (R1/R2). c Kaplan–Meier plot showing probability of survival in desflurance and propofol groups (P = 0.806, log rank test). d Cox regression model for time to death, considering the confounding factors treatment, microvascular invasion, and resection (R1/R2). HRs are shown with 95 per cent confidence intervals.
See this image and copyright information in PMC

References

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