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. 2023 Dec;38(12):2142-2151.
doi: 10.1111/jgh.16395. Epub 2023 Nov 14.

SCD Probiotics mitigate cafeteria diet-induced liver damage in Wistar rats during development

Taha Ceylani  1   2 , Harun Önlü  1   2 , Seda Keskin  3 , Hüseyin Allahverdi  1 , Hikmet Taner Teker  4
Affiliations

SCD Probiotics mitigate cafeteria diet-induced liver damage in Wistar rats during development

Taha Ceylani et al. J Gastroenterol Hepatol. 2023 Dec.

Abstract

Background and aim: The liver plays a critical role in metabolic homeostasis, and its health is often compromised by poor dietary habits. This study aimed to investigate the therapeutic potential of SCD Probiotics in mitigating adverse liver effects induced by a cafeteria diet in male Wistar rats during their developmental period.

Methods: Four groups of seven male Wistar rats each were subjected to different dietary regimens from day 21 (weaning) to day 56. The groups were as follows: a control group on normal feed; a probiotic-supplemented group on normal feed; a group on a cafeteria diet mixed with normal feed; and a group on a cafeteria diet mixed with normal feed, supplemented with SCD Probiotics. Liver health was assessed using Fourier transform infrared spectroscopy and histopathological evaluations.

Results: Rats on the cafeteria diet exhibited significant disruptions in lipid, protein, cholesterol, triglyceride levels, and glycogen/phosphate content. Histopathological abnormalities such as lymphocytic infiltration, steatosis, and necrosis were also observed. However, SCD Probiotics supplementation led to notable improvements in the liver's biomolecular composition and mitigated histopathological abnormalities. Serum liver enzyme levels (AST, ALT, ALP, and LDH) also showed beneficial effects, while serum albumin levels remained stable.

Conclusions: SCD Probiotics demonstrated a promising potential to counteract the adverse liver effects induced by a cafeteria diet in male Wistar rats. The study revealed significant improvements in biomolecular composition, histopathology, and serum enzyme levels. However, these findings are preliminary and necessitate further in vivo studies and clinical trials for validation.

Keywords: SCD Probiotics; Wistar rat; cafeteria diet-induced liver damage; development period.

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References

    1. Zenardini B, Amir M, Silveira D, Sagae SC, Paula L. Cafeteria Diet And Obesity: Mutagenicity in Wistar rats and consequences on female offspring. 2017;07(Popkin 2006):16016-9.
    1. Maeda Júnior AS, Constantin J, Utsunomiya KS et al. Cafeteria diet feeding in young rats leads to hepatic steatosis and increased gluconeogenesis under fatty acids and glucagon influence. Nutrients 2018; 10: 1-25, 1571.
    1. Heden TD, Morris EM, Kearney ML et al. Differential effects of low-fat and high-fat diets on fed-state hepatic triacylglycerol secretion, hepatic fatty acid profiles, and DGAT-1 protein expression in obese-prone Sprague-Dawley rats. Appl. Physiol. Nutr. Metab. 2014 Apr; 39: 472-479.
    1. Buyukdere Y, Gulec A, Akyol A. Cafeteria diet increased adiposity in comparison to high fat diet in young male rats. PeerJ. 2019; 2019: e6656.
    1. Srinivasan M, Katewa SD, Palaniyappan A, Pandya JD, Patel MS. Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood. Am. J. Physiol. Endocrinol. Metab. 2006; 291: 792-799.

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