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. 2023 Nov 14.
doi: 10.1111/1754-9485.13602. Online ahead of print.

Neuroimaging manifestations of paediatric histiocytoses

Hsern Ern Ivan Tan  1   2 , Rahul Lakshmanan  1   3 , Richard Warne  1 , Thomas Walwyn  3   4 , Derek Roebuck  1   3
Affiliations

Neuroimaging manifestations of paediatric histiocytoses

Hsern Ern Ivan Tan et al. J Med Imaging Radiat Oncol. .

Abstract

Histiocytoses are rare multi-system disorders marked by abnormal histiocyte cell proliferation, affecting children with diverse clinical presentations. Classified into five groups in 2016, including Langerhans-related (L), cutaneous (C), malignant (M), Rosai-Dorfman disease (R) and haemophagocytic lymphohistiocytosis (H), newer entities such as ALK-positive histiocytosis have also emerged, heralding the era of molecular (sub)classification. Common entities include Langerhans cell histiocytosis (LCH), Erdheim-Chester disease (ECD), Rosai-Dorfman disease (RDD) and haemophagocytic lymphohistiocytosis (HLH). This pictorial essay aids radiologists in recognising and differentiating paediatric histiocytoses based on unique neuroimaging features.

Keywords: head and neck imaging; magnetic resonance imaging; neuroradiology; oncologic imaging; paediatric imaging.

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