Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Nov 9:16:3241-3248.
doi: 10.2147/CCID.S431856. eCollection 2023.

Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-Control

Mahmoud Ahmed Ali  1 , Moustafa Adam El Taieb  1 , Eisa Mohamed Hegazy  2 , Hassan M Ibrahim  2 , Alshimaa Abbas Mohamed  1 , Mohamed Amer Ahmed Abdellatif  1 , Nour Mohammed Ahmed  3 , Ali Mohamed Younis  1
Affiliations

Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-Control

Mahmoud Ahmed Ali et al. Clin Cosmet Investig Dermatol. .

Abstract

Background: In the entire world, acne vulgaris (AV) is the most prevalent skin condition. Approximately 9.4% of people worldwide have acne vulgaris. This study compared the blood levels of chitinase 3-like protein 1 (YKL-40) in acne vulgaris patients before and after oral isotretinoin therapy.

Patients and methods: The design of the study was cross-sectional case-control. Forty patients with moderate to severe acne vulgaris and twenty healthy participants participated in this study. Using the Global Acne Grading System (GAGS) score, patients with acne vulgaris were evaluated both before and after concluding their treatment. Using the enzyme-linked immunosorbent assay (ELISA), the serum levels of YKL-40 were measured before and after oral isotretinoin therapy in healthy controls and acne patients.

Results: Patients with acne vulgaris had considerably greater serum levels of YKL-40 than healthy control subjects (p 0.001) did. After three months of oral isotretinoin medication, the GAGS score and blood levels of YKL-40 in acne vulgaris patients both significantly decreased.

Conclusion: The conclusion of this study was that reducing the blood levels of YKL-40 and the GAGS score in patients with acne vulgaris who took oral isotretinoin for three months was a crucial strategy.

Keywords: GAGS; YKL-40; acne vulgaris; isotretinoin.

PubMed Disclaimer

Conflict of interest statement

The authors reported no potential conflicts of interest.

Figures

Figure 1
Figure 1
Patient before treatment (A) and after treatment (B).
Figure 2
Figure 2
Patient before treatment (A) and after treatment (B).
Figure 3
Figure 3
Patient before treatment (A) and after treatment (B).
See this image and copyright information in PMC

References

    1. Sharara M, Diab H, Reda AER. A pilot study on serum lactoferrin in patients with mild versus severe acne in correlation with disease duration. J Egypt Women Dermatol Soc. 2019;16(3):193–197. doi:10.4103/JEWD.JEWD_35_19 - DOI
    1. Heng AHS, Chew FT. Systematic review of the epidemiology of acne vulgaris. Sci Rep. 2020;10(1):1–29. doi:10.1038/s41598-020-62715-3 - DOI - PMC - PubMed
    1. Greydanus DE, Azmeh R, Cabral MD, Dickson CA, Patel DR. Acne in the first three decades of life: an update of a disorder with profound implications for all decades of life. Dis Month. 2021;67(4):101103. doi:10.1016/j.disamonth.2020.101103 - DOI - PubMed
    1. Khaled HN, Hamid WGA, Alghobashy Y. Chitinase-3 protein-like-1 as inflammatory marker and disturbed lipid-profile risk in acne vulgaris. Menoufia Med J. 2022;35(2):477. doi:10.4103/mmj.mmj_271_21 - DOI
    1. Patnaik S, Purohit D, Biswasroy P, Diab WM, Dubey A. Recent advances for commedonal acne treatment by employing lipid nanocarriers topically. Int J Health Sci. 2022;6:180–205. doi:10.53730/ijhs.v6nS8.9671 - DOI