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Review
. 2023 Nov 1:16:100493.
doi: 10.1016/j.resplu.2023.100493. eCollection 2023 Dec.

Wolf Creek XVII Part 7: Mechanical circulatory support

Cindy H Hsu  1   2 , George Trummer  3 , Jan Belohlavek  4 , Demetris Yannopoulos  5 , Jason A Bartos  5
Affiliations
Review

Wolf Creek XVII Part 7: Mechanical circulatory support

Cindy H Hsu et al. Resusc Plus. .

Abstract

Introduction: Failure to restore spontaneous circulation remains a major cause of death for cardiac arrest (CA) patients. Mechanical circulatory support, specifically extracorporeal cardiopulmonary resuscitation (ECPR), has emerged as a feasible and efficacious rescue strategy for selected refractory CA patients.

Methods: Mechanical Circulatory Support was one of six focus topics for the Wolf Creek XVII Conference held on June 14-17, 2023 in Ann Arbor, Michigan, USA. Conference invitees included international thought leaders and scientists in the field of CA resuscitation from academia and industry. Participants submitted via online survey knowledge gaps, barriers to translation and research priorities for each focus topic. Expert panels used the survey results and their own perspectives and insights to create and present a preliminary unranked list for each category that was debated, revised and ranked by all attendees to identify the top 5 for each category.

Results: Top 5 knowledge gaps included optimal patient selection, pre-ECPR treatments, logistical and programmatic characteristics of ECPR programs, generalizability and effectiveness of ECPR, and prevention of reperfusion injury. Top 5 barriers to translation included cost/resource limitations, technical challenges, collaboration across multiple disciplines, limited patient population, and early identification of eligible patients. Top 5 research priorities focused on comparing the outcomes of prehospital/rapid transport strategies vs in-hospital ECPR initiation, implementation of high-performing ECPR system vs standard care, rapid patient identification tools vs standard clinical judgment, post-cardiac arrest bundled care vs no bundled care, and standardized ECPR clinical protocol vs routine care.

Conclusion: This overview can serve as an innovative guide to transform the care and outcome of patients with refractory CA.

Keywords: Cardiac arrest; Extracorporeal cardiopulmonary resuscitation; Mechanical circulatory support; Wolf Creek Conference.

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Conflict of interest statement

Cindy H. Hsu was the lead investigator of the EROCA trial and Editorial Board Member of Resuscitation Plus. Jason A. Bartos and Demetris Yannopoulos were the lead investigators of the ARREST trial. Jan Belohlavek was the lead investigator of the Prague OHCA study. George Trummer was the lead investigator for the Controlled Automated Reperfusion of the whoLe body (CARL). None of the authors have any financial conflicts of interests.

Figures

Figure 1
Figure 1
Mechanical circulatory support: Top 5 knowledge gaps as ranked by attendees at Wolf Creek XVII, June 15-17, 2023, Ann Arbor, MI
Figure 2
Figure 2
Mechanical circulatory support: Top 5 barriers to translation as ranked by attendees at Wolf Creek XVII, June 15-17, 2023,  Ann Arbor, MI
Figure 3
Figure 3
Mechanical circulatory support: Top 5 research priorities as ranked by attendees at Wolf Creek XVII, June 15-17, 2023,  Ann Arbor, MI
See this image and copyright information in PMC

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