Ectopic Pituitary Neuroendocrine Tumor: A Case Report Written With the Help of ChatGPT

Abstract

ChatGPT (Chat Generative Pre-trained Transformer) is a chat robot program developed by OpenAI (OpenAI Incorporated, Mission District, San Francisco, USA). It is a natural-language processing tool driven by artificial intelligence technology. It can complete tasks such as writing emails, video scripts, copywriting, translation, coding, and writing papers. At present, several studies have been conducted on the use of this tool for academic writing, so we report a rare case of suprasellar ectopic pituitary neuroendocrine tumor (PitNET) secreting growth hormones, in a female 53-year-old patient with facial changes and hypertrophy of her hands and feet for six years. When asking questions on unusual topics, ChatGPT can provide answers but not specific ones, and similar to most machine learning solutions, verifying the correctness of information is a problem. Question asked from ChatGPT: Summarize ectopic pituitary neuroendocrine tumor. "Suprasellar heterotopic pituitary neuroendocrine tumors refer to tumors formed by the heterotopic growth of pituitary neuroendocrine tumor cells in the sellar region other than the pituitary glands. This tumor is common in middle-aged women, and it often manifests as headache, visual impairment, and endocrine dysfunction. Diagnosis is usually made by combining history, physical examination, blood tests, and imaging. Treatment is primarily performed through surgical resection of the tumor, radiotherapy, and drug therapy, and the prognosis is mostly good." The content in quotation marks is generated by ChatGPT.

Keywords: artificial intelligence; brain tumor; chatgpt; ectopic pituitary neuroendocrine tumor; neuro-oncology.

Figure 1. Preoperative MRI of the pituitary gland

(A) Sagittal position on T1WI, a round-like isointense shadow could be observed in the suprasellar region; (B) sagittal position on T2WI, a round-like low-signal shadow can be seen; (C) sagittal position of T1 contrast enhancement. A round-like soft tissue mass was observed in the suprasellar region with mild enhancement (white arrow), clear boundary, and pituitary gland located at the posterior and inferior parts of the lesion

Figure 2. Microscopic findings during operation using the supraorbital lateral approach

(A) Tumor in the anterior cruciate space (white arrow), right optic nerve (asterisk); (B) complete pituitary stalk (white arrow); (C) the sellar diaphragm is intact, and no evident manifestation of tumor origin is observed

Figure 3. MRI of the pituitary gland reexamined seven days after surgery

(A) Sagittal position on T1WI, complete pituitary stalk (white arrow); (B) coronal position on T1WI, complete resection of the tumor was observed

Figure 4. Postoperative histopathological sections

(A) Tumor cells can present a glandular tubular structure; (B) visible perivascular pseudorosette; (C) acidophilic fine particles can be seen in the cytoplasm

Figure 5. Use of ChatGPT

Figure 6. Creating a table using ChatGPT