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Review
. 2023 Dec 1;37(15):2271-2286.
doi: 10.1097/QAD.0000000000003704. Epub 2023 Nov 16.

Considerations for long-acting antiretroviral therapy in older persons with HIV

Jesse G O'Shea  1 , Preetam Cholli  1 , Emily L Heil  2 , Kate Buchacz  1
Affiliations
Review

Considerations for long-acting antiretroviral therapy in older persons with HIV

Jesse G O'Shea et al. AIDS. .

Abstract

People with HIV (PWH) can now enjoy longer, healthier lives due to safe and highly effective antiretroviral therapy (ART), and improved care and prevention strategies. New drug formulations such as long-acting injectables (LAI) may overcome some limitations and issues with oral antiretroviral therapy and strengthen medication adherence. However, challenges and questions remain regarding their use in aging populations. Here, we review unique considerations for LAI-ART for the treatment of HIV in older PWH, including benefits, risks, pharmacological considerations, implementation challenges, knowledge gaps, and identify factors that may facilitate uptake of LA-ART in this population.

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Conflict of interest statement

Conflicts of interest

There are no conflicts of interest.

Figures

Fig. 1.
Fig. 1.
Age-related changes affecting oral ART adherence and pharmacology.
See this image and copyright information in PMC

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