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. 2023 Nov 15:151:1-16.
doi: 10.1017/S0950268823001814. Online ahead of print.

Seroprevalence of Zika in Brazil stratified by age and geographic distribution

Viviane Botosso, Alexander Roberto Precioso, Annelies Wilder-Smith, Danielle Oliveira, Fabyano Oliveira, Cairo Oliveira, Camila Soares, Lucyana Oliveira, Ralyria Santos, Carla Utescher, Francisco Coutinho, Eduardo Massad

Seroprevalence of Zika in Brazil stratified by age and geographic distribution

Viviane Botosso et al. Epidemiol Infect. .

Abstract

Congenital Zika is a devastating consequence of maternal Zika virus infections. Estimates of age-dependent seroprevalence profiles are central to our understanding of the force of Zika virus infections. We set out to calculate the age-dependent seroprevalence of Zika virus infections in Brazil. We analyzed serum samples stratified by age and geographic location, collected from 2016 to 2019, from about 16,000 volunteers enrolled in a Phase 3 dengue vaccine trial led by the Institute Butantan in Brazil. Our results show that Zika seroprevalence has a remarkable age-dependent and geographical distribution, with an average age of the first infection varying from region to region, ranging from 4.97 (3.03–5.41) to 7.24 (6.98–7.90) years. The calculated basic reproduction number, formula image , varied from region to region, ranging from 1.18 (1.04–1.41) to 2.33 (1.54–3.85). Such data are paramount to determine the optimal age to vaccinate against Zika, if and when such a vaccine becomes available.

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Figures

Figure 1.
Figure 1.
Sites of sample collection.
Figure 2.
Figure 2.
Seroprevalence data (dots) and the continuous function (Equation (4)) adjusted to the data of Brazil as a whole and to the seven collection sites. The continuous line represents the average and the dotted lines represent the 95% confidence interval.
Figure 3.
Figure 3.
Age-dependent forces of infection as calculated according to Equation (6). The continuous lines represent the average and the dotted lines represent the 95% confidence intervals.
See this image and copyright information in PMC

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