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. 1986 Dec;6(12):4450-7.
doi: 10.1128/mcb.6.12.4450-4457.1986.

Human proto-oncogene N-myc encodes nuclear proteins that bind DNA

G Ramsay, L Stanton, M Schwab, J M Bishop

Human proto-oncogene N-myc encodes nuclear proteins that bind DNA

G Ramsay et al. Mol Cell Biol. 1986 Dec.

Abstract

N-myc is a gene whose amplification has been implicated in the genesis of several malignant human tumors. We have identified two proteins with molecular weights of 65,000 and 67,000 encoded by N-myc. The abundance of these proteins in tumor cells was consonant with the extent of amplification of N-myc. The two proteins apparently arose from the same mRNA, were phosphorylated, were exceptionally unstable, were located in the nucleus of cells, and bound to both single- and double-stranded DNA. These properties suggest that the products of N-myc and of the related proto-oncogene c-myc may have similar biochemical functions and that N-myc may be a regulatory gene. Our findings sustain the view that inordinate expression of N-myc may contribute to the genesis of several different human tumors.

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