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. 1986 Dec;6(12):4770-4.
doi: 10.1128/mcb.6.12.4770-4774.1986.

Transcriptional activation of the mouse Mx gene by type I interferon

P Staeheli, P Danielson, O Haller, J G Sutcliffe

Transcriptional activation of the mouse Mx gene by type I interferon

P Staeheli et al. Mol Cell Biol. 1986 Dec.

Abstract

Mouse cells of the Mx+ genotype accumulate Mx mRNA in response to type I interferon (IFN). Nuclear runoff experiments show that IFN stringently regulates Mx gene expression at the level of transcription. Mx mRNA synthesis peaks about 3 h after IFN treatment, and within 5 h, Mx mRNA concentration rises from undetectable levels to about 0.1% of polyadenylated RNA.

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