Bacteriophage Virus-Like Particles: Platforms for Vaccine Design
- PMID: 37966612
- DOI: 10.1007/978-1-0716-3549-0_24
Bacteriophage Virus-Like Particles: Platforms for Vaccine Design
Abstract
Virus-like particles (VLPs) derived from bacteriophages have many applications in biomedical sciences, especially in the development of candidate vaccines against viral and bacterial infections. Bacteriophage VLPs can be manufactured cheaply and in large quantities in bacteria compared to eukaryotic expression systems. In addition to this, bacteriophage VLPs are excellent platforms for vaccine design for the following reason: Humans do not have preexisting antibodies against bacteriophage VLPs. Thus, antigens displayed on bacteriophage VLP platforms are expected to be highly immunogenic. As such, VLPs derived from MS2, PP7, Qβ, AP205, P22 bacteriophages, etc. have been used to develop candidate vaccines against human infectious and noninfectious agents. This mini-review summarizes data from some of the candidate bacteriophage-based VLP peptide vaccines that have been developed. The review also highlights some strategies used to develop the candidate bacteriophage-based VLP peptide vaccines.
Keywords: Bacteriophages; VLPs; Vaccines; Virus-like particles.
© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
Similar articles
-
Virus-like Particle Vaccines and Platforms for Vaccine Development.Viruses. 2023 May 2;15(5):1109. doi: 10.3390/v15051109. Viruses. 2023. PMID: 37243195 Free PMC article. Review.
-
Immunization with phage virus-like particles displaying Zika virus potential B-cell epitopes neutralizes Zika virus infection of monkey kidney cells.Vaccine. 2018 Feb 28;36(10):1256-1264. doi: 10.1016/j.vaccine.2018.01.056. Epub 2018 Feb 1. Vaccine. 2018. PMID: 29395533
-
Novel expression of coat proteins from thermophilic bacteriophage ΦIN93 and evaluation for assembly into virus-like particles.Protein Expr Purif. 2021 Nov;187:105932. doi: 10.1016/j.pep.2021.105932. Epub 2021 Jun 29. Protein Expr Purif. 2021. PMID: 34214599 Free PMC article.
-
Preclinical refinements of a broadly protective VLP-based HPV vaccine targeting the minor capsid protein, L2.Vaccine. 2015 Jun 26;33(29):3346-53. doi: 10.1016/j.vaccine.2015.05.016. Epub 2015 May 21. Vaccine. 2015. PMID: 26003490 Free PMC article.
-
Affinity selection of epitope-based vaccines using a bacteriophage virus-like particle platform.Curr Opin Virol. 2015 Apr;11:76-82. doi: 10.1016/j.coviro.2015.03.005. Epub 2015 Mar 29. Curr Opin Virol. 2015. PMID: 25829254 Free PMC article. Review.
Cited by
-
Exosome-Mediated Antigen Delivery: Unveiling Novel Strategies in Viral Infection Control and Vaccine Design.Vaccines (Basel). 2024 Mar 7;12(3):280. doi: 10.3390/vaccines12030280. Vaccines (Basel). 2024. PMID: 38543914 Free PMC article. Review.
-
Nasal and Ocular Immunization with Bacteriophage Virus-like Particle Vaccines Elicits Distinct Systemic and Mucosal Antibody Profiles.Vaccines (Basel). 2025 Aug 3;13(8):829. doi: 10.3390/vaccines13080829. Vaccines (Basel). 2025. PMID: 40872915 Free PMC article.
-
Identifying Key Drivers of Efficient B Cell Responses: On the Role of T Help, Antigen-Organization, and Toll-like Receptor Stimulation for Generating a Neutralizing Anti-Dengue Virus Response.Vaccines (Basel). 2024 Jun 14;12(6):661. doi: 10.3390/vaccines12060661. Vaccines (Basel). 2024. PMID: 38932390 Free PMC article.
-
Bacteriophages of Thermophilic 'Bacillus Group' Bacteria-A Systematic Review, 2023 Update.Int J Mol Sci. 2024 Mar 8;25(6):3125. doi: 10.3390/ijms25063125. Int J Mol Sci. 2024. PMID: 38542099 Free PMC article.
References
-
- Dion MB, Oechslin F, Moineau S (2020) Phage diversity, genomics and phylogeny. Nat Rev Microbiol 18(3):125–138. https://doi.org/10.1038/s41579-019-0311-5 - DOI - PubMed
-
- Liu H, Kheirvari M, Tumban E (2023) Potential applications of thermophilic bacteriophages in one health. Int J Mol Sci 24(9). https://doi.org/10.3390/ijms24098222
-
- Huang L, Xiang Y (2020) Structures of the tailed bacteriophages that infect Gram-positive bacteria. Curr Opin Virol 45:65–74. https://doi.org/10.1016/j.coviro.2020.09.002 - DOI - PubMed
-
- Yap ML, Rossmann MG (2014) Structure and function of bacteriophage T4. Future Microbiol 9(12):1319–1327. https://doi.org/10.2217/fmb.14.91 - DOI - PubMed
-
- Pumpens P, Pushko P (2022) Virus-like particles: a comprehensive guide. CRC Pr I Llc, Boca Raton - DOI
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials
