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. 2023 Nov 14;56(11):2469-2471.
doi: 10.1016/j.immuni.2023.10.006.

Et tu neutrophils? The brain reprograms neutrophils to facilitate tumor progression

James L Ross  1 , Dolores Hambardzumyan  2
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Et tu neutrophils? The brain reprograms neutrophils to facilitate tumor progression

James L Ross et al. Immunity. .
Free article

Abstract

Neutrophils have remained understudied in malignant brain tumors. In a recent issue of Cell, Maas et al. analyze brain tumor-patient samples and demonstrate that the brain microenvironment reprograms infiltrating neutrophils to enhance their longevity and increase their immune-suppressive and pro-angiogenic properties.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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  • The local microenvironment drives activation of neutrophils in human brain tumors.
    Maas RR, Soukup K, Fournier N, Massara M, Galland S, Kornete M, Wischnewski V, Lourenco J, Croci D, Álvarez-Prado ÁF, Marie DN, Lilja J, Marcone R, Calvo GF, Santalla Mendez R, Aubel P, Bejarano L, Wirapati P, Ballesteros I, Hidalgo A, Hottinger AF, Brouland JP, Daniel RT, Hegi ME, Joyce JA. Maas RR, et al. Cell. 2023 Oct 12;186(21):4546-4566.e27. doi: 10.1016/j.cell.2023.08.043. Epub 2023 Sep 27. Cell. 2023. PMID: 37769657

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