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Comment
. 2023 Dec 6;14(23):4062-4063.
doi: 10.1021/acschemneuro.3c00692. Epub 2023 Nov 15.

Expectancy Effects Cannot Be Neglected in MDMA-Assisted Therapy Research

L Jacob Flameling  1 , Jacob S Aday  2 , Michiel van Elk  1
Affiliations
Comment

Expectancy Effects Cannot Be Neglected in MDMA-Assisted Therapy Research

L Jacob Flameling et al. ACS Chem Neurosci. .
No abstract available

Keywords: MDMA-assisted psychotherapy; blinding; placebo-effects; post-traumatic stress disorder.

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Conflict of interest statement

The authors declare no competing financial interest.

Comment on

  • MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial.
    Mitchell JM, Ot'alora G M, van der Kolk B, Shannon S, Bogenschutz M, Gelfand Y, Paleos C, Nicholas CR, Quevedo S, Balliett B, Hamilton S, Mithoefer M, Kleiman S, Parker-Guilbert K, Tzarfaty K, Harrison C, de Boer A, Doblin R, Yazar-Klosinski B; MAPP2 Study Collaborator Group. Mitchell JM, et al. Nat Med. 2023 Oct;29(10):2473-2480. doi: 10.1038/s41591-023-02565-4. Epub 2023 Sep 14. Nat Med. 2023. PMID: 37709999 Free PMC article. Clinical Trial.

References

    1. Mitchell J. M.; et al. MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial. Nat. Med. 2023, 29, 2473. 10.1038/s41591-023-02565-4. - DOI - PMC - PubMed
    1. Aday J. S.; et al. Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials. Psychopharmacology 2022, 239, 1989–2010. 10.1007/s00213-022-06123-7. - DOI - PMC - PubMed
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    1. Mitchell J. M.; et al. MDMA-assisted therapy for severe PTSD: A randomized, double-blind, placebo-controlled phase 3 study. Nat. Med. 2021, 27, 1025–1033. 10.1038/s41591-021-01336-3. - DOI - PMC - PubMed
    1. Muthukumaraswamy S. D.; Forsyth A.; Lumley T. Blinding and expectancy confounds in psychedelic randomized controlled trials. Expert Rev. Clin. Pharmacol. 2021, 14, 1133–1152. 10.1080/17512433.2021.1933434. - DOI - PubMed

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