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Multicenter Study
. 2023;72(9):1138-1146.
doi: 10.15036/arerugi.72.1138.

[A MULTICENTER CLINICAL SURVEY ABOUT THE PREVALENCE OF JAPANESE CYPRESS POLLINOSIS AND THE EFFICACY OF SUBLINGUAL IMMUNOTHERAPY WITH JAPANESE CEDAR POLLEN EXTRACT DURING JAPANESE CYPRESS POLLEN DISPERSAL PERIOD]

[Article in Japanese]
Aiko Oka  1 , Atsushi Yuta  2 , Yukiko Okawa  2 , Satoru Masuno  3 , Takatsugu Tsunoda  4 , Eriko Takahara  5 , Akihiko Terada  6 , Kenichi Kanai  7 , Hitoshi Nagakura  8 , Hideya Mimura  9 , Harumi Arao  10 , Shigehiro Ueyama  11 , Akiyo Ueyama  11 , Reiko Tokuda  12 , Hitoshi Bamba  13 , Hidehisa Nakazato  14 , Mahoko Nakazato  14 , Ryo Amesara  15 , Shigeru Nakai  16 , Susumu Araki  17 , Mayuko Sakaida  18 , Masaharu Tokuriki  19 , Takemitsu Hama  20 , Mayumi Chiba  21 , Hiroki Ikeda  22 , Akihisa Togawa  23 , Hideaki Tsuzuki  24 , Yukiyoshi Hyo  25 , Sumiko Niitsu  26 , Chikahisa Ohkawa  27 , Setsuo Nakamoto  28 , Tetsu Takeo  29 , Hiroshi Kumanomidou  30 , Kengo Kanai  1 , Hiroshi Kitamura  1 , Ruka Sugiura  31 , Mitsuhiro Okano  1
Affiliations
Multicenter Study

[A MULTICENTER CLINICAL SURVEY ABOUT THE PREVALENCE OF JAPANESE CYPRESS POLLINOSIS AND THE EFFICACY OF SUBLINGUAL IMMUNOTHERAPY WITH JAPANESE CEDAR POLLEN EXTRACT DURING JAPANESE CYPRESS POLLEN DISPERSAL PERIOD]

[Article in Japanese]
Aiko Oka et al. Arerugi. 2023.

Abstract

Background: Little is known whether sublingual immunotherapy using Japanese cedar pollen extract (cedar SLIT) is effective for not only Japanese cedar pollinosis but also Japanese cypress pollinosis. We investigated the prevalence rate of Japanese cypress pollinosis, efficacy of cedar SLIT on cypress pollinosis and patients' wish to receive cypress SLIT.

Methods: We investigated a multi-center (31 institutions), cross-sectional survey using a self-administrated questionnaire with four questions for patients received cedar SLIT aged from 5 to 69 years old.

Results: 2523 subjects were enrolled for analysis. 83.4% of them had pollinosis symptoms during cypress season before cedar SLIT. In such patients, 37.4% experienced lessened efficacy of cedar SLIT during cypress season. Both the prevalence of cypress pollinosis and the lessened efficacy of cedar SLIT on cypress pollinosis were significantly seen in western Japan as compared to eastern Japan. 76.1% of the subject having cypress pollinosis before SLIT wished to receive cypress SLIT if it is available.

Conclusion: A lessened efficacy of cedar SLIT during cypress season was broadly seen in Japan, and further showed a regional difference. Together with the finding of high wish by patients, these results suggest a development of cypress SLIT is desirable.

Keywords: Japanese cedar pollinosis; Japanese cypress pollinosis; allergen component; questionnaire; sublingual immunotherapy.

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