Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://atm.amegroups.org/article/view/10.21037/atm-23-1603/coif). MVB received honoraria from GSK, AstraZeneca, and Daiichi Sankyo, travel support from Daiichi Sankyo, Novartis, and AstraZeneca, and has a leadership role at ESMO. JPG receives honoraria from AstraZeneca, Gilead, Seattle Genetics, Roche, MSD, Esai, Daiichi Sankyo and Lilly. IE received honoraria from Novartis, travel support from Daiichi Sankyo. MG received honoraria from AstraZeneca, Gilead and Novartis, travel support from Roche and Pfizer and advisory from Gilead. AL received research support from roche, Agendia, Lilly, Pfizer, Novartis, Merck Sharp& Dhome, Gilead and Daiichi Sankyo, advisory from Lilly, Roche, Pfizer, Novartis; Speaker’s Bureaus from Lilly, Astrazeneca, Merck Sharp&Dhome, travel support from Roche, Pfizer, Astrazeneca and Stock or other ownership: MAJ3 Capital and Initia-Research. SB received consulting/advisor from Daiichi Sankyo, AstraZeneca, honoraria from Daiichi Sankyo and AstraZeneca, Travel support from Daiichi Sankyo and AstraZeneca. JC received consulting/advisor: Roche, Celgene, Cellestia, AstraZeneca, Seattle Genetics, Daiichi Sankyo, Erytech, Athenex, Polyphor, Lilly, Merck Sharp& Dohme, GSK, Leuko, Bioasis, Clovis Oncology, Boehringer Ingelheim, Ellipses, Hibercell, BioInvent, Gemoab, Gilead, Menarini, Zymeworks, Reveal Genomics, Expres2ion Biotechnologies, Jazz Pharmaceuticals and Abbvie. Honoraria from Roche, Novartis, Celgene, Eisai, Pfizer, Samsung Bioepis, Lilly, Merck Sharp&Dhome, Daiichi Sankyo, and Astrazeneca. Research funding to the Institution from Roche, Ariad Pharmaceuticals, AstraZeneca, Baxalta GMBH/Servier Affaires, Bayer Healthcare, Eisai, F.Hoffman-La Roche, Guardanth health, Merck Sharp&Dhome, Pfizer, Piqur Therapeutics, Iqvia, Queen Mary University of London. Stock: MAJ3 Capital, Leuko (relative), travel and accommodation expenses from Roche, Novartis, Eisai, pfizer, Daiichi Sankyo, AstraZeneca, Gilead, Merck Sharp&Dhome; Patents: Pharmaceutical Combinations of A Pi3k Inhibitor And A Microtubule Destabilizing Agent. Javier Cortés Castán, Alejandro Piris Giménez, Violeta Serra Elizalde. WO 2014/199294 A. ISSUED Her2 as a predictor of response to dual HER2 blockade in the absence of cytotoxic therapy. Aleix Prat, Antonio Llombart, Javier Cortés.US 2019/ 0338368 A1. LICENSED. The authors have no other conflicts of interest to declare.