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. 2023 Dec 14;67(12):e0110423.
doi: 10.1128/aac.01104-23. Epub 2023 Nov 16.

In vitro manogepix susceptibility testing of South African Emergomyces africanus, Emergomyces pasteurianus, and Blastomyces emzantsi clinical isolates

Silondiwe P Nzimande  1 , Nelesh P Govender  1   2   3 , Tsidiso G Maphanga  1
Affiliations

In vitro manogepix susceptibility testing of South African Emergomyces africanus, Emergomyces pasteurianus, and Blastomyces emzantsi clinical isolates

Silondiwe P Nzimande et al. Antimicrob Agents Chemother. .

Abstract

We performed in vitro antifungal susceptibility testing of manogepix against the yeast phase of 78 Emergomyces africanus, 2 Emergomyces pasteurianus, and 5 Blastomyces emzantsi isolates using a reference broth microdilution method following Clinical and Laboratory Standards Institute recommendations. All three pathogens had low minimum inhibitory concentrations ranging from <0.0005 to 0.008 mg/L. Manogepix should be investigated in animal models and potentially in future human clinical trials for endemic mycoses.

Keywords: APX001A; antifungal susceptibility testing; blastomycosis; emergomycosis; manogepix; thermally dimorphic fungi.

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Conflict of interest statement

The authors declare no conflict of interest.

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