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Published Erratum
. 2023 Nov 16;142(20):1758.
doi: 10.1182/blood.2023022676.

Jutzi JS, Marneth AE, Ciboddo M, et al. Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs. Blood. 2022;140(11):1291-1304

No authors listed
Published Erratum

Jutzi JS, Marneth AE, Ciboddo M, et al. Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs. Blood. 2022;140(11):1291-1304

No authors listed. Blood. .
No abstract available

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Figures

Figure 3.
Figure 3.
In-depth validation of the N-glycan biosynthesis pathway as an essential pathway for growth of mutant CALR-expressing hematopoietic cells. (B) Growth curves of independent biological replicates and the 2 different sgRNAs were combined in the analysis. Cells were assayed either in the presence or absence of IL3 (+IL3/−IL3) for up to 96 hours. The assay was performed n = 3 for all 4 biological replicates of both genotypes. Statistical significance was determined by 2-way analysis of variance (ANOVA). Mean plus and minus standard error of the mean (SEM). ∗∗∗∗P < .00001. The most important statistical analysis is highlighted.
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