Becoming fluent in proteins
- PMID: 37972558
- DOI: 10.1016/j.cels.2023.10.008
Becoming fluent in proteins
Abstract
Large language models have emerged as a new compass for navigating the complex landscapes of protein engineering. This issue of Cell Systems features ProGen2 and IgLM-two protein language models (PLMs) that use subtly different approaches to design proteins.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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IgLM: Infilling language modeling for antibody sequence design.Cell Syst. 2023 Nov 15;14(11):979-989.e4. doi: 10.1016/j.cels.2023.10.001. Epub 2023 Oct 30. Cell Syst. 2023. PMID: 37909045 Free PMC article.
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ProGen2: Exploring the boundaries of protein language models.Cell Syst. 2023 Nov 15;14(11):968-978.e3. doi: 10.1016/j.cels.2023.10.002. Epub 2023 Oct 30. Cell Syst. 2023. PMID: 37909046