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Review
. 2024 Jan;8(1):63-74.
doi: 10.1016/S2352-4642(23)00232-8. Epub 2023 Nov 14.

Coeliac disease: what can we learn from prospective studies about disease risk?

Marisa Stahl  1 , Sibylle Koletzko  2 , Carin Andrén Aronsson  3 , Katri Lindfors  4 , Edwin Liu  5 , Daniel Agardh  3 ; TEDDY Study Group
Affiliations
Review

Coeliac disease: what can we learn from prospective studies about disease risk?

Marisa Stahl et al. Lancet Child Adolesc Health. 2024 Jan.

Abstract

Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric prospective studies on genetic and environmental risk factors for coeliac disease. In addition, recent omics studies have made it possible to study complex interactions between genetic and environmental factors and thereby further our insight into the causes of the disease. In the future, paediatric prospective studies will be able to provide more detailed risk prediction models combining genes, the environment, and biological corroboration from multiomics. Such studies could also contribute to biomarker development and an improved understanding of disease pathogenesis.

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Conflict of interest statement

Declaration of interests MS has received consulting fees from Pfizer (the Data and Safety Monitoring Board for coeliac disease clinical trials) and Takeda (coeliac disease advisory board). SK has received consulting fees from Danone, has received honoraria from Mead Johnson, Takeda, Nestl.to T Nestlé Nutrition, and Pfizer, and has participated on advisory boards for Takeda, Sanofi, Danone, GlaxoKlineSmith, and Janssen. CAA has grants or contracts with the Swedish Celiac Disease Foundation, Albert Pahlssons Foundation, Maggie Stephens Foundation, Fanny Ekdahls Foundation, Lions Forskningsfond Skane, and Ake Wibergs Foundation. EL and MS have grants or contracts from JDRF and Helmsley Charitable Trust Foundation for the Autoimmunity Screening for Kids study and consult for UptoDate. KL has grants from The Academy of Finland (347473), the Sigrid Juselius Foundation, European Union's Horizon 2020 research and innovation programme (grant agreement No 874864), has received support to attend conferences, serves on the Scientific Advisory Board of The Finnish Celiac Society, and serves as treasurer of the Multi Society Celiac Disease Consortium. EL has received consulting fees from Takeda and serves on the Scientific Advisory Board for the Celiac Disease Foundation and Beyond Celiac. DA has grants or contracts from Lions forskiningsfond Skane, SUS fonder, RoU projektmedel, Swedish Celiac Disease Foundation, Swedish Research Council (Grant 2018-02553; 2022-000537), SFBS Forskningsmedel, ALF projektmedel, Swedish Childhood Diabetes Foundation, EU Interreg, H2020-SCI-2019, NIH/NIDDK 1 R01 DK124581-01, has received support to attend conferences, is co-inventor of a patent with Probi AB, Sweden, has received consulting fees from Takeda and serves on the Scientific Advisory Board for Allero Therapeutics and the Swedish Celiac Disease Research Foundation.

Figures

Figure 1:
Figure 1:. Published Risk Factors From Prospective Coeliac Disease Studies Impacting Later Coeliac Disease Development
This figure highlights genetic and environmental risk factors discussed in this review from prospective coeliac disease studies that increase the risk of coeliac disease (red box), decrease the risk of coeliac disease (green box), or do not impact coeliac disease risk (yellow box).
See this image and copyright information in PMC

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