Diclofenac-induced hepatotoxicity
- PMID: 3797366
- PMCID: PMC2418538
- DOI: 10.1136/pgmj.62.723.63
Diclofenac-induced hepatotoxicity
Abstract
Two patients developed clinical, biochemical and histopathological signs of a liver hypersensitivity reaction following treatment with diclofenac. Hepatic side effects of this drug are very rare. The relevant literature is reviewed.
Similar articles
-
Diclofenac-associated hepatotoxicity.JAMA. 1990 Nov 28;264(20):2660-2. JAMA. 1990. PMID: 2232043
-
Diclofenac hepatitis.Aust N Z J Med. 1991 Apr;21(2):251-5. doi: 10.1111/j.1445-5994.1991.tb00455.x. Aust N Z J Med. 1991. PMID: 1872757 Review.
-
Hepatotoxicity to several nonsteroidal anti-inflammatory drugs with diclofenac induced histological changes.Clin Rheumatol. 1992 Mar;11(1):120-1. doi: 10.1007/BF02207099. Clin Rheumatol. 1992. PMID: 1582111 No abstract available.
-
Diclofenac induced hepatitis. 3 cases with features of autoimmune chronic active hepatitis.Dig Dis Sci. 1993 Apr;38(4):744-51. doi: 10.1007/BF01316809. Dig Dis Sci. 1993. PMID: 8462374 Review.
-
Hypersensitivity reaction to sulfasalazine with severe hepatotoxicity.Gastroenterology. 1978 Jul;75(1):95-9. Gastroenterology. 1978. PMID: 45581
Cited by
-
Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.Drugs. 1988 Mar;35(3):244-85. doi: 10.2165/00003495-198835030-00004. Drugs. 1988. PMID: 3286213 Review.
-
Characterization of dasatinib and its structural analogs as CYP3A4 mechanism-based inactivators and the proposed bioactivation pathways.Drug Metab Dispos. 2009 Jun;37(6):1242-50. doi: 10.1124/dmd.108.025932. Epub 2009 Mar 12. Drug Metab Dispos. 2009. PMID: 19282395 Free PMC article.
-
Diclofenac hepatitis.Gut. 1991 Nov;32(11):1381-5. doi: 10.1136/gut.32.11.1381. Gut. 1991. PMID: 1752473 Free PMC article.
-
Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention.Drug Saf. 1996 Jul;15(1):64-71. doi: 10.2165/00002018-199615010-00005. Drug Saf. 1996. PMID: 8862964 Review.
-
Renal and hepatic impairment in association with diclofenac administration.Postgrad Med J. 1989 Jul;65(765):507-8. doi: 10.1136/pgmj.65.765.507-a. Postgrad Med J. 1989. PMID: 2602249 Free PMC article. No abstract available.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical