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Review
. 2023 Dec;201(6):521-529.
doi: 10.1007/s00408-023-00661-3. Epub 2023 Nov 16.

Lung Cancer in Never Smokers: Delving into Epidemiology, Genomic and Immune Landscape, Prognosis, Treatment, and Screening

Ayse Ece Cali Daylan  1 , Emily Miao  2 , Kevin Tang  2 , Grace Chiu  3 , Haiying Cheng  4
Affiliations
Review

Lung Cancer in Never Smokers: Delving into Epidemiology, Genomic and Immune Landscape, Prognosis, Treatment, and Screening

Ayse Ece Cali Daylan et al. Lung. 2023 Dec.

Abstract

Lung cancer in never smokers (LCINS) represents a growing and distinct entity within the broader landscape of lung malignancies. This review provides a comprehensive overview of LCINS, encompassing its epidemiologic trends, risk factors, distinct genomic alterations, clinical outcomes and the ongoing initiative aimed at formulating screening guidelines tailored to this unique population. As LCINS continues to gain prominence, understanding its intricate genomic landscape has become pivotal for tailoring effective therapeutic strategies. Moreover, LCINS does not meet the criteria for lung cancer screening as per the current guidelines. Hence, there is an urgent need to explore its heterogeneity in order to devise optimal screening guidelines conducive to early-stage detection. This review underscores the vital importance of detailed research to elucidate the multifaceted nature of LCINS, with the potential to shape future clinical management and screening recommendations for this unique and growing patient cohort.

Keywords: Genomic landscape; Lung cancer; NSCLC; Never smoker; SCLC; Screening.

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References

    1. Sung H et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 Countries. CA Cancer J Clin 71(3):209–249 - PubMed - DOI
    1. Siegel RL et al (2023) Cancer statistics, 2023. CA Cancer J Clin 73(1):17–48 - PubMed - DOI
    1. Moolgavkar SH et al (2012) Impact of reduced tobacco smoking on lung cancer mortality in the United States during 1975–2000. J Natl Cancer Inst 104(7):541–548 - PubMed - PMC - DOI
    1. Klemperer EM et al (2021) Tobacco and nicotine use among US adult “Never Smokers” in wave 4 (2016–2018) of the population assessment of tobacco and health study. Nicotine Tob Res 23(7):1199–1207 - PubMed - PMC - DOI
    1. Parkin DM et al (2005) Global cancer statistics, 2002. CA Cancer J Clin 55(2):74–108 - PubMed - DOI

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