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. 2023 Dec;75(4):3895-3897.
doi: 10.1007/s12070-023-03962-4. Epub 2023 Jun 15.

Histoplasmosis Masquerading as Second Primary in Head and Neck Tumours - A Case Report

Gowthame K  1 , Annapurneswari S  2 , Kannan S  3 , Archana L  2
Affiliations

Histoplasmosis Masquerading as Second Primary in Head and Neck Tumours - A Case Report

Gowthame K et al. Indian J Otolaryngol Head Neck Surg. 2023 Dec.

Abstract

Histoplasmosis is a chronic granulomatous disease seen in immunocompromised individuals, rarely immunocompetent patients. We report disseminated histoplasmosis involving adrenal glands and oral cavity with synchronous squamous cell carcinoma of right pyriform fossa. With early diagnosis and treatment he recovered well.

Supplementary information: The online version contains supplementary material available at 10.1007/s12070-023-03962-4.

Keywords: Histoplasmosis; Pyriform fossa; Squamous cell carcinoma.

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Conflict of interest statement

Conflict of InterestNil.

Figures

Fig. 1
Fig. 1
2 × 1 cm ulcerated lesion involving right lower alveolus
Fig. 2
Fig. 2
PET CT image showing FDG uptake in Right pyriform fossa
Fig. 3
Fig. 3
PET CT image showing FDG uptake in Bilateral adrenal glands
Fig. 4
Fig. 4
A(H&E-40X) & B(H&E-400X) – Squamous cell carcinoma with keratinisation C(H&E-1000X) D(PAS- 1000X) Scattered Hisptoplasma organisms shown in arrow marks
See this image and copyright information in PMC

References

    1. Prabhash K, Babu G, Chaturvedi P, Kuriakose M, Birur P, Anand AK, Kaushal A, Mahajan A, Syiemlieh J, Singhal M, Gairola M (2020) Indian clinical practice consensus guidelines for the management of squamous cell carcinoma of head and neck. Indian Journal of Cancer. Feb 1;57(5):1 - PubMed
    1. Randhawa HS, Gugnani HC. Occurrence of histoplasmosis in the indian sub-continent: an overview and update. J Med Res Pract. 2018;7(3):71–83.
    1. Dogenski LC, Pasqualotto EM, Dutra MJ, Rovani G, Trentin MS, De Carli JP (2022) Uncommon case of histoplasmosis with oral manifestation: A case report of diagnosis in a South American patient. International Journal of Surgery Case Reports. Apr 1;93:106920 - PMC - PubMed
    1. Singh A, Gauri M, Gautam P, Gautam D, Haq M, Handa AC, Handa KK (2019) Head and neck involvement with histoplasmosis; the great masquerader. American journal of otolaryngology. Sep 1;40(5):678 – 83 - PubMed
    1. Viswanathan S, Chawla N, D’Cruz A, Kane SV (2007 Dec) Head and neck histoplasmosis—a nightmare for clinicians and pathologists! Experience at a tertiary referral cancer centre. Head Neck Pathol 1(1):169–172 - PMC - PubMed

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