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. 2023 Dec;75(4):3364-3372.
doi: 10.1007/s12070-023-03922-y. Epub 2023 Jun 22.

Histological Characteristics of Chronic Allergic Rhinitis Versus Non-allergy: Is There a Difference in the Remodeling?

Carlos Ríos-Deidán  1 , Maria-Soledad Reyes  2 , Tamara Acosta-Castillo  3 , Edgar Escalante-Fiallos  4 , Diana Villacrés-Silva  4
Affiliations

Histological Characteristics of Chronic Allergic Rhinitis Versus Non-allergy: Is There a Difference in the Remodeling?

Carlos Ríos-Deidán et al. Indian J Otolaryngol Head Neck Surg. 2023 Dec.

Abstract

Demonstrate the histological remodeling changes in the turbinates, identify the frequency of the two forms of rhinitis in the samples studied and determine the remodeling differences found in the two variants. Patients attended an otolaryngology service at the Social Security Hospital of city Sangolqui-Ecuador from February 2016 to June 2017. The allergic variant was determined when eosinophils were found by higher magnification field and non-allergic when they were not found in the submucosal segment. Epithelial, inflammatory, and stromal markers were analyzed. One hundred twenty histopathological samples were analyzed, 75% presented allergic rhinitis, the age averaged 36.2 years. When we compared between the allergic and non-allergic variants: epithelial and stromal markers we had significant differences, as well as between each of its components; except fibrosis. In relation to the inflammatory pattern, there were significant differences between the number of mast cells and stromal markers with eosinophils > 10 by field. The allergic type corresponded to 75% of patients with persistent severe rhinitis who underwent turbinectomy. Regarding remodeling, there was a statistically significant difference in favor of the allergic variant. Eosinophilia greater than 10 was directly related to mastocytosis and subepithelial edema.

Keywords: Allergic rhinitis; Eosinophils; Histology; Mast cells; Nasal mucosa; Turbinates; Vasomotor rhinitis.

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Conflict of interest statement

Conflict of interestAll authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.

Figures

Fig. 1
Fig. 1
Epithelial markers and their comparative analysis between allergic and non-allergic after Mann Whitney U test
Fig. 2
Fig. 2
a Basal membrane thickness 14 µm. b Scamous metaplasia
Fig. 3
Fig. 3
Stromal markers and their comparative analysis between allergy and non-allergy after Mann Whitney U test (AR: allergy rhinitis. NAR: no allergy rhinitis)
Fig. 4
Fig. 4
Edema moderate—marked
Fig. 5
Fig. 5
Differences between factors in patients with allergic rhinitis after Kruskal Wallis test (EM: epithelial markers. SM: stromal markers. IM: inflammatory markers)
Fig. 6
Fig. 6
Comparison of mast cells, epithelial markers, stromal with respect eosinophils (< 10 and > 10), in allergic rhinitis after Mann Whitney U test
Fig. 7
Fig. 7
a Eosinophils > 10 by FHM. b Eosinophil aggregates
See this image and copyright information in PMC

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