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. 2023 Dec;75(4):3750-3756.
doi: 10.1007/s12070-023-04057-w. Epub 2023 Jul 20.

Regional Nodal Recurence as a Prognostic Factor in Patients Kept on Observation for cT1-T2 Oral Squamous Cell Carcinomas of Tongue: A Meta-Analysis of 11,973 Patients

Mohammad Akheel  1   2 , Ashmi Wadhwania  3 , Vinay Venkataramu  4 , Tanvi Vijay  5 , Mukhallat Qazi  6 , Ridhima Suneja  1
Affiliations

Regional Nodal Recurence as a Prognostic Factor in Patients Kept on Observation for cT1-T2 Oral Squamous Cell Carcinomas of Tongue: A Meta-Analysis of 11,973 Patients

Mohammad Akheel et al. Indian J Otolaryngol Head Neck Surg. 2023 Dec.

Abstract

The surgical management of the clinically node negative neck in T1-T2 early oral tongue squamous cell carcinoma (OTSCC) has been the topic of debate since few decades. As the occult cervical lymph node metastasis is considered to be the primary prognostic factor in early OTSCC, this meta-analysis has been carried out to find the risk of regional nodal recurrence on patients kept under observation than those who have underwent Elective neck dissection (END). The articles were electronically retrieved from Ovid Medline, PubMed, Cochrane and Scholar for comparison of Observation versus END in early OTSCC. The search strategy identified 35 relevant review articles from April 1979 to April 2020 from different search engines. A total of 11,973 patients from 30 retrospective analyses, 4 prospective and 1 randomized control trials were included in this meta-analysis. Overall test revealed (OR: 13.02 95% CI 1.360-17.154) with t test 2.382 and p value 0.023 which is statistically significant and showed that END significantly reduced the risk of regional nodal recurrence. This meta-analysis finds that there is statistically significant relationship when END was performed which reduced the risk of regional nodal recurrence as seen in patients kept on Observation thereby affecting the Overall survival (OS) rate.

Keywords: Carcinoma tongue; Elective neck dissection; Nodal recurrence; Observation; Prognosis.

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Conflict of interest statement

Conflict of interestThe authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Tabulation of HR of all 35 articles to find Nodal recurrence in END versus observation
See this image and copyright information in PMC

References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Global Health Estimates (2016) Deaths by cause, age, sex, by country and by region, 2000–2016. Geneva, World Health Organization; 2018; Human Development Report 2016. New York, United Nations Development Programme; 2016
    1. Bagan J, Sarrion G, Jimenez Y. Oral cancer: clinical features. Oral Oncol. 2010;46(414–7):4. - PubMed
    1. Ow TJ, Myers JN. Current management of advanced resectable oral cavity squamous cell carcinoma. Clin Exp Otorhinolaryngol. 2011;4:1–10. doi: 10.3342/ceo.2011.4.1.1. - DOI - PMC - PubMed
    1. Funk GF, Karnell LH, Robinson RA, Zhen WK, Trask DK, Hoffman HT. Presentation, treatment, and outcome of oral cavity cancer: a national cancer data base report. Head Neck. 2002;24:16580. doi: 10.1002/hed.10004. - DOI - PubMed

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