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Review
. 2023 Jul 14;22(2):985-994.
doi: 10.1007/s40200-023-01256-8. eCollection 2023 Dec.

Metabolomics signature of cardiovascular disease in patients with diabetes, a narrative review

Salimeh Dodangeh  1 , Hananeh Taghizadeh  1 , Shaghayegh Hosseinkhani  2 , Pouria Khashayar  3 , Parvin Pasalar  4 , Hamid Reza Aghaei Meybodi  5 , Farideh Razi  2 , Bagher Larijani  1
Affiliations
Review

Metabolomics signature of cardiovascular disease in patients with diabetes, a narrative review

Salimeh Dodangeh et al. J Diabetes Metab Disord. .

Abstract

Objectives: The exact underlying mechanism of developing diabetes-related cardiovascular disease (CVD) among patients with type 2 diabetes (T2D) is not clear. Metabolomics can provide a platform enabling the prediction, diagnosis, and understanding of the risk of CVD in patients with diabetes mellitus. The aim of this review is to summarize the available evidence on the relationship between metabolomics and cardiovascular diseases in patients with diabetes.

Methods: The literature was searched to find out studies that have investigated the relationship between the alteration of specific metabolites and cardiovascular diseases in patients with diabetes.

Results: Evidence proposed that changes in the metabolism of certain amino acids, lipids, and carbohydrates, independent of traditional CVD risk factors, are associated with increased CVD risk.

Conclusions: Metabolomics can provide a platform to enable the prediction, diagnosis, and understanding of the risk of CVD in patients with diabetes mellitus. The association of the alteration in specific metabolites with CVD may be considered in the investigations for the development of new therapeutic targets for the prevention of CVD in patients with diabetes mellitus.

Keywords: Cardiovascular disease; Diabetes mellitus; Metabolomics; Review.

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Conflict of interest statement

Conflict of interestThe authors declared that they have no conflict of interest.

References

    1. Tabish SA. Is diabetes becoming the biggest epidemic of the twenty-first century? Int J health Sci. 2007;1(2):V. - PMC - PubMed
    1. International Diabetes Federation. IDF Diabetes Atlas, 10th ed. ; 2021. https://diabetesatlas.org/atlas/tenth-edition/.
    1. Moradi-Lakeh M, El Bcheraoui C, Khalil I, Charara R, Afshin A, Wang H, et al. Diabetes mellitus and chronic kidney disease in the Eastern Mediterranean Region: findings from the global burden of Disease 2015 study. Int J Public Health. 2018;63(1):177–86. - PMC - PubMed
    1. Selvin E, Marinopoulos S, Berkenblit G, Rami T, Brancati FL, Powe NR, et al. Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med. 2004;141(6):421–31. - PubMed
    1. Wei M, Gaskill SP, Haffner SM, Stern MP. Effects of diabetes and level of glycemia on all-cause and cardiovascular mortality. The San Antonio Heart Study. Diabetes Care. 1998;21(7):1167–72. - PubMed

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