Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep 24;22(2):1763-1768.
doi: 10.1007/s40200-023-01311-4. eCollection 2023 Dec.

Benefits in routinely measured liver function tests following bariatric surgery: a retrospective cohort study

Richard Roberts  1 , David M Williams  1   2 , Thinzar Min  2   3   4 , Jonathan Barry  5 , Jeffrey W Stephens  1   3
Affiliations

Benefits in routinely measured liver function tests following bariatric surgery: a retrospective cohort study

Richard Roberts et al. J Diabetes Metab Disord. .

Abstract

Background: Bariatric surgery is well-established to support long-term metabolic health benefits associated with considerable weight loss. Here, we aim to determine the longer-term impact of bariatric surgery on liver enzymes and associations with other metabolic improvements.

Methods: One hundred patients who underwent bariatric surgery between 2007 and 2014 were included, and changes in liver enzymes, anthropometric measures and other parameters were observed over a mean 9.8 years.

Results: At the time of surgery, the mean age was 45.4 ± 9.6 years, weight 141.2 ± 31.6 kg, and body mass index (BMI) 50.2 ± 10.1 kg/m2. Most patients underwent sleeve gastrectomy [n = 71] with a mean follow-up duration 9.8 ± 2.3 years. From baseline, alanine transaminase (ALT) reduced by 41.3% within 12 months post-operatively (36.6 ± 29.2 U/L to 21.5 ± 14.9 U/L, p < 0.001), which was sustained at recent follow-up (20.2 ± 10.7 U/L, p < 0.001). There were associated reductions in body weight, BMI, HbA1c, blood pressure and triglycerides. Patients with greater baseline ALT had the greatest reduction in ALT over follow-up.

Conclusions: Bariatric surgery is associated with rapid and sustained improvements in routine liver enzymes at 10 years, and sustained improvements in features of the metabolic syndrome.

Supplementary information: The online version contains supplementary material available at 10.1007/s40200-023-01311-4.

Keywords: Bariatric surgery; Metabolic syndrome; NAFLD; Non-alcoholic fatty liver disease; Obesity; Weight loss.

PubMed Disclaimer

Conflict of interest statement

Competing interestsOn behalf of all authors, the corresponding author states that there is no conflict of interest.

Similar articles

See all similar articles

Cited by

References

    1. Shah M, Simha V, Garg A. Long-term impact of bariatric surgery on Body Weight, Comorbidities, and Nutritional Status. J Clin Endocrinol Metab. 2006;91:4223–31. doi: 10.1210/jc.2006-0557. - DOI - PubMed
    1. Kaul A, Sharma J. Impact of bariatric surgery on comorbidities. Surg Clin North Am. 2011;91:1295–312. doi: 10.1016/j.suc.2011.08.003. - DOI - PubMed
    1. Lim R, Beekley A, Johnson DC, Davis KA. Early and late complications of bariatric operation. Trauma Surg Acute Care Open. 2018;3:e000219. doi: 10.1136/tsaco-2018-000219. - DOI - PMC - PubMed
    1. Khosravi-Largani M, Nojomi M, Aghili R, Otaghvar HA, Tanha K, Seyedi SHS, et al. Evaluation of all types of metabolic bariatric surgery and its Consequences: a systematic review and Meta-analysis. Obes Surg. 2019;29:651–90. doi: 10.1007/s11695-018-3550-z. - DOI - PubMed
    1. Głuszyńska P, Lemancewicz D, Dzięcioł JB, Razak Hady H. Non-alcoholic fatty liver Disease (NAFLD) and Bariatric/Metabolic surgery as its treatment option: a review. J Clin Med. 2021;10:5721. doi: 10.3390/jcm10245721. - DOI - PMC - PubMed

LinkOut - more resources