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Review
. 2023 Aug 29;22(2):1021-1028.
doi: 10.1007/s40200-023-01277-3. eCollection 2023 Dec.

Animal models for induction of diabetes and its complications

Faiz Qamar  1 , Shirin Sultana  1 , Manju Sharma  1
Affiliations
Review

Animal models for induction of diabetes and its complications

Faiz Qamar et al. J Diabetes Metab Disord. .

Abstract

Objectives: Animal models are widely used to develop newer drugs for treatment of diabetes and its complications. We conducted a systematic review to find various animal models to induce diabetes and also the suitable methods in various diabetic complications. With an emphasis on the animal models of diabetes induction, this review provides a basic overview of diabetes and its various types. It focused on the use of rats and mice for chemical, spontaneous, surgical, genetic, viral, and hormonal induction approaches.

Methods: All observations and research conducted on Diabetes and its complications published up to 18 May 2023 in PubMed, Web of Science, Scopus and Conchrane Library databases were included. Main outcome measures were reporting the induction of diabetes in experimental animals, the various animal models for diabetic complications including diabetic nephropathy, diabetic retinopathy, diabetic neuropathy and diabetic osteopathy. The quality of reporting of included articles and risk of bias were assessed.

Results: We reached various articles and found that rats and mice are the most frequently used animals for inducing diabetes. Chemical induction is the most commonly used followed by spontaneous and surgical methods. With slight modification various breeds and species are developed to study and induce specific complications on eyes, kidneys, neurons and bones.

Conclusions: Our review suggested that rats and mice are the most suitable animals. Furthermore, chemical induction is the method frequently used by experimenters. Moreover, high quality studies are required to find the suitable methods for diabetic complications.

Keywords: Animal models; Diabetic complications; Diabetogens; Experimental models; STZ-Diabetes.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Mechanism of action of STZ
See this image and copyright information in PMC

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