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Review
. 2023 Dec;59(6):1114-1122.
doi: 10.1111/jpy.13400. Epub 2023 Nov 17.

Phaeodactylum tricornutum: An established model species for diatom molecular research and an emerging chassis for algal synthetic biology

Monia T Russo  1 , Alessandra Rogato  2   3 , Marianne Jaubert  4 , Bogumil J Karas  5 , Angela Falciatore  4
Affiliations
Review

Phaeodactylum tricornutum: An established model species for diatom molecular research and an emerging chassis for algal synthetic biology

Monia T Russo et al. J Phycol. 2023 Dec.

Abstract

Diatoms are prominent and highly diverse microalgae in aquatic environments. Compared with other diatom species, Phaeodactylum tricornutum is an "atypical diatom" displaying three different morphotypes and lacking the usual silica shell. Despite being of limited ecological relevance, its ease of growth in the laboratory and well-known physiology, alongside the steady increase in genome-enabled information coupled with effective tools for manipulating gene expression, have meant it has gained increased recognition as a powerful experimental model for molecular research on diatoms. We here present a brief overview of how over the last 25 years P. tricornutum has contributed to the unveiling of fundamental aspects of diatom biology, while also emerging as a new tool for algal process engineering and synthetic biology.

Keywords: Phaeodactylum tricornutum; diatom; functional genomics; molecular model; synthetic biology.

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