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Randomized Controlled Trial
. 2023 Nov 17;19(12):95.
doi: 10.1007/s11306-023-02057-z.

Highlights of three metabolites HDL and reduction in blood pressure values after dietary fiber supplementation in overweight and obese normotensive women: a metabolomic study

Cássia Surama Oliveira da Silva  1 , Mussara Gomes Cavalcanti Alves Monteiro  2 , Carla Patricia Novaes Dos Santos Fechine  2 , Josean Fechine Tavares  3 , Augusto Lopes Souto  3 , Rafaella Cristhine Pordeus Luna  2 , Flávia Cristina Fernandes Pimenta  4 , Ana Herminia Andrade E Silva  5 , Alcides da Silva Diniz  6 , Celso Costa da Silva Júnior  2 , Caio César Ferreira Alverga  7 , Sócrates Golzio Dos Santos  3 , Darlene Camati Persuhn  2 , Maria José de Carvalho Costa  2
Affiliations
Randomized Controlled Trial

Highlights of three metabolites HDL and reduction in blood pressure values after dietary fiber supplementation in overweight and obese normotensive women: a metabolomic study

Cássia Surama Oliveira da Silva et al. Metabolomics. .

Abstract

Introduction: The prevalence of hypertension and obesity are a worldwide concern.

Objetives: Assess the metabolites profile after intervention with mixed dietary fiber in overweight and obese normotensive women.

Methods: This is a randomized double blind placebo-controlled study. Through a simple randomization process, two groups were allocated, with eleven women (group 1) receiving 12 g of mixed dietary fiber and thirteen women (group 2) receiving 12 g of placebo (corn starch) for eight weeks. Anthropometric and biochemical tests and lifestyle were analyzed. As for evaluation metabolomics, used a 1H NMR. The data matrix generated 96 samples and 225 variables, which was exported in the ASCII format for the "The Unscrumbler" statistics software (version 9.7, CAMO Process).

Results: After the intervention with mixed dietary fiber, significant differences were observed between the main types of metabolites, referring to the increase in the relative peak areas of in three HDL metabolites 4.94 ppm (0.0086*), HDL 1.28 ppm (0 .0337*), HDL 0.88 ppm (0.0224*) and an α-glucose metabolite 4.90 ppm (0.0106) and the reduction in systolic blood pressure (SBP) (0.0292*) of 7 mmHg in the reference range and in the placebo group there was a reduction in SBP (0.0118*) of 4 mmHg and of a choline metabolite 3.65 ppm (0.0266*), which does not call into question the validity of these results in the literature.

Conclusion: The synergism of the functions of these statistically highlighted metabolites contributed to prevention the increase in SBP after fiber intervention in overweight and obese normotensive women.

Keywords: Blood pressure; Dietary fiber; Metabolome; Nuclear magnetic resonance.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
1H NMR multivariate data analysis extracted from serum analysis of overweight and obese normotensive women before and after mixed dietary fiber intervention. Statistical tool - Principal Component Analysis (PCA). Score Plot. G1 Pre (Blue group: pre-intervention); G1 Pos (Red group: post-intervention). The G1 Pos group was differentiated due to the influence of peaks related to HDL and sugar metabolites
Fig. 2
Fig. 2
1H NMR multivariate data analysis extracted from serum analysis of overweight and obese normotensive women before and after mixed dietary fiber intervention. Statistical tool - Principal Component Analysis (PCA). Loadings Plot. Representation of all detected metabolites and their spatial influence in relation to the samples distributed in the Score Plot
Fig. 3
Fig. 3
1D Carr Purcell Meiboom Gill (CPMG) 1H NMR spectrum representative of serum metabolites. * PPM (chemical shift)
See this image and copyright information in PMC

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