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. 1986;10(3-5):533-40.
doi: 10.1016/0278-5846(86)90023-0.

Brain and brain monoamine oxidase in aging and in dementia of Alzheimer's type

L Oreland, C G Gottfries

Brain and brain monoamine oxidase in aging and in dementia of Alzheimer's type

L Oreland et al. Prog Neuropsychopharmacol Biol Psychiatry. 1986.

Abstract

Brain MAO-B activity increases with age. The rate of increase varies in different brain regions. Brain MAO-A activity does not change with age in man and is decreased in the rat. Brain MAO-B activity in AD/SDAT is higher than in age-matched controls. The increased MAO-B activity in aging is due to an increased concentration of otherwise unchanged extrasynaptosomal MAO-B. The increase in brain MAO-B activity with age and in AD/SDAT is more pronounced in white matter than in gray matter. Platelet MAO is increased in patients with AD/SDAT.

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