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Comment
. 2023 Nov 16;83(22):3950-3952.
doi: 10.1016/j.molcel.2023.10.039. Epub 2023 Nov 16.

Large-scale clustering of AlphaFold2 3D models shines light on the structure and function of proteins

Nicola Bordin  1 , Andy M Lau  2 , Christine Orengo  3
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Comment

Large-scale clustering of AlphaFold2 3D models shines light on the structure and function of proteins

Nicola Bordin et al. Mol Cell. .
Free article

Abstract

Two recent studies exploited ultra-fast structural aligners and deep-learning approaches to cluster the protein structure space in the AlphaFold Database. Barrio-Hernandez et al.1 and Durairaj et al.2 uncovered fascinating new protein functions and structural features previously unknown.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Uncovering new families and folds in the natural protein universe.
    Durairaj J, Waterhouse AM, Mets T, Brodiazhenko T, Abdullah M, Studer G, Tauriello G, Akdel M, Andreeva A, Bateman A, Tenson T, Hauryliuk V, Schwede T, Pereira J. Durairaj J, et al. Nature. 2023 Oct;622(7983):646-653. doi: 10.1038/s41586-023-06622-3. Epub 2023 Sep 13. Nature. 2023. PMID: 37704037 Free PMC article.
  • Clustering predicted structures at the scale of the known protein universe.
    Barrio-Hernandez I, Yeo J, Jänes J, Mirdita M, Gilchrist CLM, Wein T, Varadi M, Velankar S, Beltrao P, Steinegger M. Barrio-Hernandez I, et al. Nature. 2023 Oct;622(7983):637-645. doi: 10.1038/s41586-023-06510-w. Epub 2023 Sep 13. Nature. 2023. PMID: 37704730 Free PMC article.

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