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Comment
. 2023 Nov 16;30(11):1331-1333.
doi: 10.1016/j.chembiol.2023.10.017.

Fine-tuning chemical genetics to identify physiologic drug targets

Lauren E Vostal  1 , Tarun M Kapoor  2
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Fine-tuning chemical genetics to identify physiologic drug targets

Lauren E Vostal et al. Cell Chem Biol. .
Free article

Abstract

Genetics-based approaches can enable drug target identification in human cells. In this issue of Cell Chemical Biology, Nguyen et al.1 use inducible degradation of a mismatch repair protein to tune the mutation rate in HCT116 cells, thereby increasing sensitivity and selectivity in identifying resistance-conferring mutations for several cytotoxic small molecules.

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Conflict of interest statement

Declaration of interests T.M.K. is a co-founder of and has an ownership interest in RADD Pharmaceuticals, Inc.

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