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Comment
. 2023 Nov 16;30(11):1334-1336.
doi: 10.1016/j.chembiol.2023.10.007.

Addicted to proteostasis: How KRAS-driven cancers acquire resistance to clinical KRAS inhibitors

Austin T Klein  1 , Marc L Mendillo  2
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Addicted to proteostasis: How KRAS-driven cancers acquire resistance to clinical KRAS inhibitors

Austin T Klein et al. Cell Chem Biol. .
Free article

Abstract

The development of KRAS inhibitors was a remarkable feat, yet their efficacy is limited by inevitable resistance. In the September issue of Science, Lv et al.1 demonstrate how KRAS-driven cancers rewire signaling to restore protein homeostasis and acquire resistance to KRAS inhibitors with implications for novel combination therapeutic strategies.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors.
    Lv X, Lu X, Cao J, Luo Q, Ding Y, Peng F, Pataer A, Lu D, Han D, Malmberg E, Chan DW, Wang X, Savage SR, Mao S, Yu J, Peng F, Yan L, Meng H, Maneix L, Han Y, Chen Y, Yao W, Chang EC, Catic A, Lin X, Miles G, Huang P, Sun Z, Burt B, Wang H, Wang J, Yao QC, Zhang B, Roth JA, O'Malley BW, Ellis MJ, Rimawi MF, Ying H, Chen X. Lv X, et al. Science. 2023 Sep 8;381(6662):eabn4180. doi: 10.1126/science.abn4180. Epub 2023 Sep 8. Science. 2023. PMID: 37676964 Free PMC article.

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