Health-related quality of life among adolescents and young adults with mood and anxiety concerns

Ayman A Kazi^{1

2}, Elizabeth A Osuch^{3

4

5}, Michael Wammes^{3

4

5}, Ava John-Baptiste^{1

4

5

6

7

8}

Affiliations

¹ Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.
² Michael DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
³ Department of Psychiatry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
⁴ London Health Sciences Centre, London, ON, Canada.
⁵ Lawson Health Research Institute, London, ON, Canada.
⁶ Schulich Interfaculty Program in Public Health, Western University, London, ON, Canada.
⁷ Department of Anesthesia and Perioperative Medicine, Western University, London, ON, Canada.
⁸ Centre for Medical Evidence, Decision Integrity and Clinical Impact, London, ON, Canada.

PMID: 37978940
PMCID: PMC10945981
DOI: 10.1177/13591045231214286

Health-related quality of life among adolescents and young adults with mood and anxiety concerns

Ayman A Kazi et al. Clin Child Psychol Psychiatry. 2024 Apr.

. 2024 Apr;29(2):550-563.

doi: 10.1177/13591045231214286. Epub 2023 Nov 18.

Authors

Ayman A Kazi^{1

2}, Elizabeth A Osuch^{3

4

5}, Michael Wammes^{3

4

5}, Ava John-Baptiste^{1

4

5

6

7

8}

Affiliations

¹ Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.
² Michael DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
³ Department of Psychiatry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
⁴ London Health Sciences Centre, London, ON, Canada.
⁵ Lawson Health Research Institute, London, ON, Canada.
⁶ Schulich Interfaculty Program in Public Health, Western University, London, ON, Canada.
⁷ Department of Anesthesia and Perioperative Medicine, Western University, London, ON, Canada.
⁸ Centre for Medical Evidence, Decision Integrity and Clinical Impact, London, ON, Canada.

PMID: 37978940
PMCID: PMC10945981
DOI: 10.1177/13591045231214286

Abstract

Objectives: To characterize health related quality of life (HRQOL) for Canadians aged 16 to 25 (adolescents and young adults, AYAs) seeking care for mood and anxiety concerns at the First Episode Mood and Anxiety Program, in London, Ontario and to identify factors associated with HRQOL in this population.

Methods: AYAs completed demographic, psychometric, and HRQOL questionnaires. We calculated 36-Item Short-Form Health Survey (SF-36) scores standardized to Canadian and US population norms. We computed Short Form 6 Dimension (SF-6D) utilities conducting multivariable linear regression analysis, adjusting for age, sex, ethnoracial minority status, parental marital/cohabitation status, parental education, the Anxiety Sensitivity Index (ASI-R), Montgomery-Åsberg Depression Rating Scale Self-Report (MADRS-S), Sheehan Disability Scale (SDS), and a modified Inventory of College Students' Recent Life Experiences (ICSRLE-M).

Results: Amongst 182 AYAs who completed questionnaires, mean physical component summary (PCS), mental component summary (MCS) and SF-6D utility scores were low, 43.8 (SD = 16.6), 19.0 (SD = 11.9) and .576 (SD = .074), respectively. Maternal post-secondary education, depression (MADRS-S) and functional impairment (SDS) were significantly associated with SF-6D utility.

Conclusion: This cohort of mental healthcare-seeking AYAs had significantly impaired psychometric and utility-based measures of quality of life, underscoring the importance of timely access to healthcare services for this population.

Keywords: Health-related quality of life; SF-6 dimension; adolescents; anxiety disorders; first episode mood and anxiety program; health utility; mood and anxiety disorders; mood disorders; short-form 36; young adult.

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Conflict of interest statement

Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

**Figure 1.**
Sample distribution of SF-6D scores with kernel density (in red) and a normal distribution (in green) with sample mean (.576) and standard deviation (.074) (N = 182).

See this image and copyright information in PMC

References

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Health-related quality of life among adolescents and young adults with mood and anxiety concerns

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Health-related quality of life among adolescents and young adults with mood and anxiety concerns

Authors

Affiliations

Abstract

Conflict of interest statement

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References

MeSH terms

Supplementary concepts

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Medical