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Meta-Analysis
. 2023 Nov 20;38(1):268.
doi: 10.1007/s10103-023-03938-4.

Does aPDT reduce bacterial load in endodontic infected teeth? A systematic review and meta-analysis

Ramiro Martins Quintana  1 , Roberta Kochenborger Scarparo  1 , Eliseu Aldrighi Münchow  1 , Lucas Siqueira Pinheiro  1 , Cauana Oliva Tavares  1 , Patricia Maria Poli Kopper  2
Affiliations
Meta-Analysis

Does aPDT reduce bacterial load in endodontic infected teeth? A systematic review and meta-analysis

Ramiro Martins Quintana et al. Lasers Med Sci. .

Abstract

This systematic review investigated whether antimicrobial photodynamic therapy (aPDT) after chemomechanical root canal disinfection (CD) yields a greater microbial load reduction than only CD. An electronic literature search was conducted on four databases up to November 2022, with no language or publication date restrictions. Randomized and non-randomized clinical trials were included if participants had a primary endodontic infection in permanent teeth, and if microbial loads before and after using aPDT were compared. Two researchers independently screened titles and abstracts to determine study eligibility. Assessments included risk of bias and methodological quality. This review was registered in PROSPERO (CRD42020181783). Eight studies were included in the qualitative analysis, and six were eligible for meta-analysis. In the random effects model, aPDT significantly improved the results of root canal disinfection when compared with standard protocols for cleaning and shaping (p = 0.04, 95% CI -1.72, -0.05). Subgroup analysis suggested that aPDT has a better effect on reducing the load of anaerobic microorganisms (p = 0.003, 95% CI -3.36, -0.69). The use of aPDT as an adjunct to chemomechanical disinfection promotes additional reduction of the microbial load and, therefore, seems to improve the results of root canal treatments in permanent teeth with a primary endodontic infection. However, certainty of evidence should be improved.

Keywords: Antimicrobial photodynamic therapy; Endodontics; Root canal disinfection; Systematic review.

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References

    1. de Oliveira BP, Aguiar CM, Câmara AC, de Albuquerque MM, Correia AC, Soares MF (2015) The efficacy of photodynamic therapy and sodium hypochlorite in root canal disinfection by a single-file instrumentation technique. Photodiagnosis Photodyn Ther 12:436–443. https://doi.org/10.1016/j.pdpdt.2015.05.004 - DOI - PubMed
    1. Rosa RAD, Santini MF, Figueiredo JAP, Visioli F, Pereira JR, Vivan RR et al (2017) Effectiveness of photodynamic therapy associated with irrigants over two biofilm models. Photodiagnosis Photodyn Ther 20:169–174. https://doi.org/10.1016/j.pdpdt.2017.10.003 - DOI - PubMed
    1. Wainwright M (1998) Photodynamic antimicrobial chemotherapy (PACT). J Antimicrob Chemother 42:13–28. https://doi.org/10.1093/jac/42.1.13 - DOI - PubMed
    1. Carrera ET, Dias HB, Corbi SCT, Marcantonio RAC, Bernardi ACA, Bagnato VS et al (2016) The application of antimicrobial photodynamic therapy (aPDT) in dentistry: a critical review. Laser Phys 26:123001. https://doi.org/10.1088/1054-660X/26/12/123001 - DOI - PubMed - PMC
    1. Kalka K, Merk H, Mukhtar H (2000) Photodynamic therapy in dermatology. J Am Acad Dermatol 42:389–413. https://doi.org/10.1016/s0190-9622(00)90209-3 - DOI - PubMed

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