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. 2023 Sep;11(5):801-818.
doi: 10.1177/21677026221138819. Epub 2023 Feb 7.

Hippocampal Connectivity with the Default Mode Network is Linked to Hippocampal Volume in the Clinical High Risk for Psychosis Syndrome and Healthy Individuals

Katrina Aberizk  1 , Esra Sefik  1   2 , Jean Addington  3 , Alan Anticevic  4 , Carrie E Bearden  5 , Kristin S Cadenhead  6 , Tyrone D Cannon  4 , Barbara A Cornblatt  7 , Matcheri Keshavan  8 , Daniel H Mathalon  9   10 , Diana O Perkins  11 , William S Stone  8 , Ming T Tsuang  6 , Scott W Woods  4 , Elaine F Walker  1
Affiliations

Hippocampal Connectivity with the Default Mode Network is Linked to Hippocampal Volume in the Clinical High Risk for Psychosis Syndrome and Healthy Individuals

Katrina Aberizk et al. Clin Psychol Sci. 2023 Sep.

Abstract

Reduced hippocampal volume (HV) is an established brain morphological feature of psychiatric conditions. HV is associated with brain connectivity in humans and non-human animals and altered connectivity is associated with risk for psychiatric illness. Associations between HV and connectivity remain poorly characterized in humans, and especially in phases of psychiatric illness that precede disease onset. This study examined associations between HV and hippocampal functional connectivity (FC) during rest in 141 healthy controls and 248 individuals at-risk for psychosis. Significant inverse associations between HV and hippocampal FC with the inferior parietal lobe (IPL) and thalamus were observed. Select associations between hippocampal FC and HV were moderated by diagnostic group. Significant moderation results shifted from implicating the IPL to the temporal pole after excluding participants on antipsychotic medication. Considered together, this work implicates hippocampal FC with the temporoparietal junction, within a specialized subsystem of the default mode network, as sensitive to HV.

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Conflict of interest statement

Conflicts of Interest The authors declare that there were no conflicts of interest with respect to the authorship or the publication of this article.

Figures

Figure 1.
Figure 1.
Forest plot presenting the results of linear relationships between bilateral hippocampal volume (HV) and ipsilateral and contralateral default mode network connectivity. Left ipsilateral = left HV and left hippocampal functional connectivity (FC); left contralateral = left HV and right hippocampal FC; right contralateral = right HV and left hippocampal FC; right ipsilateral = right HV and right hippocampal FC; ACC = anterior cingulate cortex; front = frontal; gyr = gyrus; med = medial; orb = orbital; parahipp = parahippocampal; PCC = posterior cingulate cortex; sup = superior; temp = temporal. *Significant after correcting for multiple comparisons using Benjamini-Hochberg method at p < .05. Bootstrapped confidence intervals presented at 75% magnitude.
Figure 2.
Figure 2.
Scatterplots present linear relationships between hippocampal functional connectivity and hippocampal volume relations that were significantly moderated by diagnostic group. In each case, the relation is modeled separately by diagnostic group. APSS = Attenuated Positive Symptom Syndrome; FC = functional connectivity; HV = hippocampal volume; IPL = inferior parietal lobe.
See this image and copyright information in PMC

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