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. 1979 Jun 25;6(8):2697-705.
doi: 10.1093/nar/6.8.2697.

Entrapment of plasmid DNA in liposomes

G J Dimitriadis
Free PMC article

Entrapment of plasmid DNA in liposomes

G J Dimitriadis. Nucleic Acids Res. .
Free PMC article

Abstract

The entrapment of plasmid DNA (pMB9) and high molecular weight DNA into large unilamellar liposomes is described. The entrapment of DNA is specific and due to encapsulation of DNA into the aqueous compartment of liposomes. The entrapped Dna, resistant to deoxyribonuclease treatment, could be reisolated from liposomes intact and, as has been shown by transformation assay, it remains biologically active. The advantages of our method and possible applications are discussed.

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