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. 2024 Sep;30(6):3866-3872.
doi: 10.1111/odi.14813. Epub 2023 Nov 20.

Site-specific radiation dosage and implant survival in oral cancer patients: A cohort study

Jamie M Alberga  1 , Arjan Vissink  1 , Anke Korfage  1 , Sebastiaan A H J de Visscher  1 , Max J H Witjes  1 , Johannes A Langendijk  2 , Gerry M Raghoebar  1
Affiliations

Site-specific radiation dosage and implant survival in oral cancer patients: A cohort study

Jamie M Alberga et al. Oral Dis. 2024 Sep.

Abstract

Objectives: We assessed the radiation dosages (Dmean) on implant regions to identify the threshold for implant loss in patients with an intraoral malignancy treated with dental implants to support a mandibular denture during ablative surgery before volumetric-modulated arc therapy (VMAT).

Materials and methods: Data was collected prospectively from 28 patients treated surgically for an intraoral malignancy, followed by postoperative radiotherapy (VMAT) and analyzed retrospectively. Patients received 2 implants in the native mandible during ablative surgery. Implant-specific Dmean values were retrieved from the patients' files. Radiographic bone loss was measured 1 year after implant placement and during the last follow-up appointment. Implant survival was analyzed with the Kaplan-Meier method. Univariate logistic regression and Cox-regression analyses were performed to investigate the effect of increasing implant-specific radiation dosages on implant loss.

Results: Five out of 56 placed implants were lost during follow-up (median 36.0 months, IQR 39.0). Radiographically, peri-implant bone loss occurred in implants with a Dmean > 40 Gy. Implant loss occurred only in implants with a Dmean > 50 Gy.

Conclusion: An implant-specific Dmean higher than 50 Gy is related to more peri-implant bone loss and, eventually, implant loss.

Keywords: Oral cancer; dental implants; implant survival; implant‐specific dose; radiotherapy.

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References

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