The immunomodulatory and antioxidant effects of β-glucans in invertebrates

Abstract

β-glucans (βGs) are carbohydrate polymers linked by β-1,3, 1,4 or 1,6 bonds, they have been used to protect against potential pathogens and prevent lethal diseases. The immune system possesses several receptors that identify a wide range of structures and trigger cellular and humoral mechanisms. However, the mechanisms by which βGs activate the immune system of invertebrate organisms have not been fully clarified. This review is focused on evaluating the effect of βGs on innate immune system in invertebrates. βGs stimulate different cellular and humoral mechanisms, such as phagocytosis, oxygen species production, extracellular trap formation, proPO system, and antimicrobial peptide synthesis, moreover, βGs increase survival rate and decrease pathogen load in several species.

Keywords: Deseases; Glucans; Immunostimulants; Invertebrate immunology.