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Randomized Controlled Trial
. 2024 Jan;40(1):e12929.
doi: 10.1111/phpp.12929. Epub 2023 Nov 20.

Narrowband ultraviolet B phototherapy combined with intralesional injection of either latanoprost or platelet-rich plasma for stable nonsegmental vitiligo

Manal Fawzy  1 , Sahar Al-Mokadem  1 , Mabrokah Alshereef  1 , Basma Elkholy  1
Affiliations
Randomized Controlled Trial

Narrowband ultraviolet B phototherapy combined with intralesional injection of either latanoprost or platelet-rich plasma for stable nonsegmental vitiligo

Manal Fawzy et al. Photodermatol Photoimmunol Photomed. 2024 Jan.

Abstract

Background: Narrowband ultraviolet B (NB-UVB) phototherapy is the cornerstone of vitiligo treatment. Its combination with other treatments usually yields a better response. Latanoprost, a prostaglandin F2α analog, and autologous platelet-rich plasma (PRP) have been reported to be effective for vitiligo.

Aim: To evaluate the efficacy of NB-UVB combined with intralesional latanoprost or PRP for stable nonsegmental vitiligo (NSV).

Methods: Sixty patients with stable NSV were recruited and randomly allocated to two equal groups. NB-UVB phototherapy was administered twice a week for all patients. Additionally, group A received intralesional latanoprost injections once weekly, while group B received intralesional autologous PRP injections every 2 weeks.

Results: At 24 weeks, excellent repigmentation response was observed in 26.7% and 13.3% of patients in the latanoprost/NB-UVB and PRP/NB-UVB groups, respectively, with no significant difference in degrees of repigmentation between the two groups. However, the Vitiligo Extent Score for a Target Area (VESTA) score was significantly higher in the latanoprost/NB-UVB group (p = .032). Moreover, lesions located on nonacral skin responded significantly better than those on acral skin. Only erythema was significantly higher in the PRP/NB-UVB group, while the recurrence of depigmentation was significantly higher in the latanoprost/NB-UVB group.

Conclusions: Both latanoprost and PRP have the potential to be effective add-on therapies to NB-UVB phototherapy for stable NSV, with latanoprost resulting in a greater repigmentation response and PRP producing a more stable response.

Keywords: latanoprost; narrowband ultraviolet B; platelet-rich plasma; treatment; vitiligo.

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References

REFERENCES

    1. Rodrigues M, Ezzedine K, Hamzavi I, Pandya AG, Harris JE, Vitiligo Working Group. New discoveries in the pathogenesis and classification of vitiligo. J Am Acad Dermatol. 2017;77(1):1-13.
    1. Brazzelli V, Antoninetti M, Palazzini S, Barbagallo T, De Silvestri A, Borroni G. Critical evaluation of the variants influencing the clinical response of vitiligo: study of 60 cases treated with ultraviolet B narrow-band phototherapy. J Eur Acad Dermatol Venereol. 2007;21(10):1369-1374.
    1. Esmat S, Hegazy RA, Shalaby S, Hu SC, Lan CE. Phototherapy and combination therapies for vitiligo. Dermatol Clin. 2017;35(2):171-192.
    1. Eldelee SA, Gheida SF, Sarhan NI, Ibrahim ZA, Elfar NN. Evaluation of the effect of combined intralesional injection of prostaglandin F2α with narrow-band UVB phototherapy in treatment of resistant cases of vitiligo. J Dermatolog Treat. 2021;32(4):383-390.
    1. Ibrahim HG, Al-Mokadem S, Esawy A. The effect of narrow-band ultraviolet B rays alone versus its combination with intralesional injection of latanoprost in the treatment of vitiligo. Ann Romanian Soc Cell Biol. 2021;25(6):14139-14151.

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