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. 2023 Dec;29(12):2563-2565.
doi: 10.3201/eid2912.231114.

OXA-48-Producing Uropathogenic Escherichia coli Sequence Type 127, the Netherlands, 2015-2022

Marlies Mulder, Daan W Notermans, Cornelia C H Wielders, Jeroen Bos, Sandra Witteveen, Varisha A Ganesh, Fabian Landman, Angela de Haan, Caroline Schneeberger-van der Linden, Antoni P A Hendrickx; Dutch CPE Surveillance Study Group1

OXA-48-Producing Uropathogenic Escherichia coli Sequence Type 127, the Netherlands, 2015-2022

Marlies Mulder et al. Emerg Infect Dis. 2023 Dec.

Abstract

During 2015-2022, a genetic cluster of OXA-48-producing uropathogenic Escherichia coli sequence type 127 spread throughout the Netherlands. The 20 isolates we investigated originated mainly from urine, belonged to Clermont phylotype B2, and carried 18 genes encoding putative uropathogenicity factors. The isolates were susceptible to first-choice antimicrobial drugs for urinary tract infections.

Keywords: Escherichia coli; OXA-48; ST127; UPEC; antimicrobial resistance; bacteria; carbapenemase-producing Enterobacterales; the Netherlands; uropathogenic Escherichia coli.

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References

    1. Notermans DW, Schoffelen AF, Landman F, Wielders CCH, Witteveen S, Ganesh VA, et al.; Dutch CPE Surveillance Study Group. A genetic cluster of OXA-244 carbapenemase-producing Escherichia coli ST38 with putative uropathogenicity factors in the Netherlands. J Antimicrob Chemother. 2022;77:3205–8. 10.1093/jac/dkac307 - DOI - PMC - PubMed
    1. IAME. Clermont typing [cited 2023 Mar 24]. http://clermontyping.iame-research.center/index.php
    1. Hendrickx APA, Landman F, de Haan A, Witteveen S, van Santen-Verheuvel MG, Schouls LM; The Dutch Cpe Surveillance Study Group. blaOXA-48-like genome architecture among carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in the Netherlands. Microb Genom. 2021;7:000512. 10.1099/mgen.0.000512 - DOI - PMC - PubMed
    1. Schreiber HL IV, Conover MS, Chou WC, Hibbing ME, Manson AL, Dodson KW, et al. Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections. Sci Transl Med. 2017;9:eaaf1283. 10.1126/scitranslmed.aaf1283 - DOI - PMC - PubMed
    1. The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters, version 13.0, 2023. [cited 2023 Jun 29]. https://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_...

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