Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Mar 15:156:22-34.
doi: 10.1016/j.semcdb.2023.11.002. Epub 2023 Nov 19.

Apoptotic signaling: Beyond cell death

Maddalena Nano  1 , Denise J Montell  2
Affiliations
Review

Apoptotic signaling: Beyond cell death

Maddalena Nano et al. Semin Cell Dev Biol. .

Abstract

Apoptosis is the best described form of regulated cell death, and was, until relatively recently, considered irreversible once particular biochemical points-of-no-return were activated. In this manuscript, we examine the mechanisms cells use to escape from a self-amplifying death signaling module. We discuss the role of feedback, dynamics, propagation, and noise in apoptotic signaling. We conclude with a revised model for the role of apoptosis in animal development, homeostasis, and disease.

Keywords: Anastasis; Apoptosis; Caspase; Feedback in apoptosis; Regulated cell death.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors have organizational affiliations, stock ownership, and research support to disclose. D.J.M. is a member of the Board of Scientific Counselors for the National Cancer Institute; has 5% equity in Mor Bio, a subsidiary of Inceptor Bio, which is a cellular immunotherapy company; and has 20% equity in Anastasis Biotechnology Corporation. The authors have patent filings to disclose: Modulation of Anastasis, UCSB Case Number 2020–062–2, US Patent found in United States Provisional Patent Application Number 63/029,380, entitled “Methods of Modulating Anastasis,” filed May 22, 2020; Detection of Anastasis, UCSB Case Number 2020–62–1, found in US Patent United States Provisional Patent Application Number 63/029,358, entitled “Methods of Detecting Anastasis,” filed May 22, 2020; US provisional application no. 63/014,049 entitled “Stimulating Phagocytosis of Cancer Cells by Activating Rac in Macrophages” filed on April 23, 2020, with docket number P2495-USP; and US provisional application no. 63/126,379 entitled “Genetically Engineered Phagocytes and Related Compositions Methods and Systems” filed on December 16, 2020, with docket number P2495-USP2. A provisional patent application entitled “Suppression of Neurodegeneration with the Zinc Transporter ZIP7” UCSB-546PRV_UC2022–758–1_ST25, was filed on September 13, 2021. D.J.M. has received research funds in the form of unrestricted gifts from the Anastasis Biotechnology Corporation and from Inceptor Bio. M.N. declares no competing interests.

LinkOut - more resources