[Prevention of stress ulcers with cimetidine and ranitidine. Comparative studies within the scope of cardiosurgical interventions]

Abstract

2 H2-receptor antagonists--Cimetidine and Ranitidine--were applied in our prospective randomized study in 100 cardio-surgical cases in order to test their therapeutical efficiency for the prophylaxis of bleedings of gastroduodenal stress-ulcers. During the phase of the intensive therapy of 2 days the patients of group A received t.i.d. 400 mg of Cimetidine i.v. and those of group B twice a day 150 mg of Ranitidine i.v. The following tests were realized: gastric acidity, plasma level, side-effects, hemorrhages and ulcers. The gastric 8 o'clock pH-level of group A (Cimetidine) during this intensive therapy was significantly (p = 0.0001) higher than the respective level of group B (Ranitidine). Other parameters were not showing any statistical differences between both groups. Acute gastro-intestinal hemorrhages because of stress-ulcers were not noticed during the test.