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. 2024 Mar;71(3):343-352.
doi: 10.1007/s12630-023-02653-6. Epub 2023 Nov 21.

Association between postinduction hypotension and postoperative mortality: a single-centre retrospective cohort study

Toshiyuki Nakanishi  1   2 , Tatsuya Tsuji  3 , Yoshiki Sento  3 , Hiroya Hashimoto  4 , Koichi Fujiwara  5 , Kazuya Sobue  3
Affiliations

Association between postinduction hypotension and postoperative mortality: a single-centre retrospective cohort study

Toshiyuki Nakanishi et al. Can J Anaesth. 2024 Mar.

Abstract
in English, French

Purpose: We aimed to elucidate whether postinduction hypotension (PIH), defined as hypotension between anesthesia induction and skin incision, and intraoperative hypotension (IOH) are associated with postoperative mortality.

Methods: We conducted a retrospective cohort study of adult patients with an ASA Physical Status I-IV who underwent noncardiac and nonobstetric surgery under general anesthesia between 2015 and 2021 at Nagoya City University Hospital. The primary and secondary outcomes were 30-day and 90-day postoperative mortality, respectively. We calculated four hypotensive indices (with time proportion of the area under the threshold being the primary exposure variable) to evaluate the association between hypotension (defined as a mean blood pressure < 65 mm Hg) and mortality using multivariable logistic regression models. We used propensity score matching and RUSBoost (random under-sampling and boosting), a machine-learning model for imbalanced data, for sensitivity analyses.

Results: Postinduction hypotension and IOH were observed in 82% and 84% of patients, respectively. The 30-day and 90-day postoperative mortality rates were 0.4% (52/14,210) and 1.0% (138/13,334), respectively. Postinduction hypotension was not associated with 30-day mortality (adjusted odds ratio [aOR], 1.03; 95% confidence interval [CI], 0.93 to 1.13; P = 0.60) and 90-day mortality (aOR, 1.01; 95% CI, 0.94 to 1.07; P = 0.82). Conversely, IOH was associated with 30-day mortality (aOR, 1.19; 95% CI, 1.12 to 1.27; P < 0.001) and 90-day mortality (aOR, 1.12; 95% CI, 1.06 to 1.19; P < 0.001). Sensitivity analyses supported the association of IOH but not PIH with postoperative mortality.

Conclusion: Despite limitations, including power and residual confounding, postoperative mortality was associated with IOH but not with PIH.

RéSUMé: OBJECTIF: Nous avons cherché à déterminer si l’hypotension post-induction (HPI), définie comme une hypotension entre l’induction de l’anesthésie et l’incision cutanée, et l’hypotension peropératoire (HPO) étaient associées à la mortalité postopératoire. MéTHODE: Nous avons mené une étude de cohorte rétrospective de patient·es adultes ayant un statut physique I-IV selon l’ASA et ayant bénéficié d’une chirurgie non cardiaque et non obstétricale sous anesthésie générale entre 2015 et 2021 à l’Hôpital universitaire de la ville de Nagoya. Les critères d’évaluation principal et secondaire étaient la mortalité postopératoire à 30 et 90 jours, respectivement. Nous avons calculé quatre indices d’hypotension (la proportion temporelle de la zone sous le seuil étant la principale variable d’exposition) pour évaluer l’association entre l’hypotension (définie comme une tension artérielle moyenne < 65 mm Hg) et la mortalité à l’aide de modèles de régression logistique multivariée. Nous avons utilisé l’appariement par score de propension et le RUSBoost (sous-échantillonnage et boosting aléatoire), un modèle d’apprentissage automatique pour les données déséquilibrées, pour les analyses de sensibilité. RéSULTATS: Une HPI et une HPO ont été observées chez 82 % et 84 % des patient·es, respectivement. Les taux de mortalité postopératoire à 30 et 90 jours étaient respectivement de 0,4 % (52/14 210) et de 1,0 % (138/13 334). L’hypotension post-induction n’était pas associée à la mortalité à 30 jours (rapport de cotes ajusté [RCa], 1,03; intervalle de confiance [IC] à 95 %, 0,93 à 1,13; P = 0,60) et à la mortalité à 90 jours (RCa, 1,01; IC 95 %, 0,94 à 1,07; P = 0,82). À l’inverse, l’HPO était associée à une mortalité à 30 jours (RCa, 1,19; IC 95 %, 1,12 à 1,27; P < 0,001) et à la mortalité à 90 jours (RCa, 1,12; IC 95 %, 1,06 à 1,19; P < 0,001). Les analyses de sensibilité ont confirmé l’association de l’HPO, mais pas de l’HPI, avec la mortalité postopératoire. CONCLUSION: Malgré les limitations, y compris la puissance et persistance de facteurs confondants, la mortalité postopératoire était associée à l’hypotension peropératoire mais pas à l’hypotension post-induction seule.

Keywords: intraoperative hypotension; noncardiac surgery; postinduction hypotension; postoperative mortality.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Study flow chart ASA-PS = American Society of Anesthesiologists Physical Status; DPC = diagnostic procedure codes
Fig. 2
Fig. 2
Feature importance of variables in the RUSBoost model for predicting 30-day postoperative mortality using hypotensive proportion of area under the curve. The boxes’ lower and upper edges represent the 25th and 75th percentiles, respectively. The medians are represented by the horizontal lines that run across the boxes. The whiskers represent the lowest and highest values from the 25th and 75th percentiles within a 1.5-box length. Outliers (extreme points beyond whiskers) are shown as dots. APTT = activated partial thromboplastin time; ASA-PS = American Society of Anesthesiologists Physical Status; BB = beta-blockade; BUN = blood urea nitrogen; BMI = body mass index; CCB = calcium blockade; DM = diabetes mellitus; eGFR = estimated glomerular filtration ratio; IOH = intraoperative hypotension; PIH = post-induction hypotension; PT-INR = prothrombin-international normalized ratio; RAAI = renin-angiotensin-aldosterone system inhibitors; TIVA = total intravenous anesthesia
See this image and copyright information in PMC

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