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. 2023 Nov;120(11):e20230378.
doi: 10.36660/abc.20230378.

Long-term Health-Related Quality of Life and Outcomes after Hospitalization for COVID-19 in Brazil: Post-COVID Brazil 1 Study Protocol

[Article in English, Portuguese]
Geraldine Trott  1 , Fernando Luis Scolari  1   2 , Marciane Maria Rover  1   2 , Mariana Motta Dias da Silva  1 , Denise de Souza  1 , Rosa da Rosa Minho Dos Santos  1 , Raíne Fogliati de Carli Schardosim  1 , Gabriela Soares Rech  1 , Juliana de Mesquita Neto  1 , Gabriel Pozza Estivalete  1 , Hellen Jordan Martins Freitas  1 , Carolina Rothmann Itaqui  1 , Amanda Christina Kozesinski-Nakatani  3 , Andreia Biolo  1   2   4 , Milena Soriano Marcolino  5 , Bruna Brandão Barreto  6   7 , Paulo Roberto Schvartzman  2 , Ana Carolina Peçanha Antonio  8 , Caroline Cabral Robinson  1 , Maicon Falavigna  4   9 , Carisi Anne Polanczyk  1   2   4 , Regis Goulart Rosa  1   10
Affiliations

Long-term Health-Related Quality of Life and Outcomes after Hospitalization for COVID-19 in Brazil: Post-COVID Brazil 1 Study Protocol

[Article in English, Portuguese]
Geraldine Trott et al. Arq Bras Cardiol. 2023 Nov.

Abstract
in English, Portuguese

Background: The long-term impact of hospitalization for COVID-19 on patients' physical, mental, and cognitive health still needs further assessment.

Objectives: This study aims to evaluate factors associated with quality of life and cardiovascular and non-cardiovascular outcomes 12 months after hospitalization for COVID-19.

Methods: This prospective multicenter study intends to enroll 611 patients hospitalized due to COVID-19 (NCT05165979). Centralized telephone interviews are scheduled to occur at three, six, nine, and 12 months after hospital discharge. The primary endpoint is defined as the health-related quality-of-life utility score assessed by the EuroQol-5D-3L (EQ-5D-3L) questionnaire at 12 months. Secondary endpoints are defined as the EQ-5D-3L at three, six and nine months, return to work or education, persistent symptoms, new disabilities in instrumental activities of daily living, cognitive impairment, anxiety, depression, and post-traumatic stress symptoms, major cardiovascular events, rehospitalization, as well as all-cause mortality at 3, 6, 9, and 12 months after SARS-CoV-2 infection. A p-value <0.05 will be assumed as statistically significant for all analyses.

Results: The primary endpoint will be presented as the frequency of the EQ-5D-3L score 12 months after COVID-19 hospitalization. A sub-analysis to identify possible associations of independent variables with study outcomes will be presented.

Conclusions: This study will determine the impact of COVID-19 on the quality of life and cardiovascular and non-cardiovascular outcomes of hospitalized patients 12 months after discharge providing insights to the public health system in Brazil.

Fundamento: O impacto em longo prazo da hospitalização por COVID-19 sobre a saúde física, mental e cognitiva dos pacientes requer mais investigação.

Objetivos: Este artigo visa avaliar os fatores associados com a qualidade de vida e desfechos cardiovasculares e não cardiovasculares 12 meses após a internação hospitalar por COVID-19.

Métodos: Este estudo multicêntrico prospectivo pretende incluir 611 pacientes internados por COVID-19 (NCT05165979). Entrevistas telefônicas centralizadas estão programadas para ocorrer em três, seis, nove e 12 meses após a alta hospitalar. O desfecho primário é definido como o escore de utilidade de qualidade de vida relacionada à saúde avaliada pelo questionário EuroQol-5D-3L (EQ-5D-3L) aos 12 meses. Desfechos secundários são definidos como o EQ-5D-3L aos três, seis e nove meses, retorno ao trabalho ou à escola, sintomas persistentes, novas incapacidades em atividades instrumentais diárias, déficit cognitivo, ansiedade, depressão, e sintomas de transtorno do estresse pós-traumático, eventos cardiovasculares maiores, reinternação, e mortalidade por todas as causas aos três, seis, nove e 12 meses após a infecção pelo SARS-CoV-2. Um valor de p<0,05 será considerado estatisticamente significativo para as análises.

Resultados: O desfecho primário será apresentado como frequência do escore EQ-5D-3L 12 meses após a internação por COVID-19. Uma subanálise para identificar possíveis associações das variáveis independentes com desfechos do estudo será apresentada.

Conclusão: Este estudo determinará o impacto da COVID-19 sobre a qualidade de vida e de desfechos cardiovasculares e não cardiovasculares de pacientes internados 12 meses após a alta, e fornecerá novas informações ao sistema público de saúde no Brasil.

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Conflict of interest statement

Potencial conflito de interesse

Geraldine Trott, Fernando Luis Scolari, Marciane Maria Rover, Mariana Motta Dias da Silva, Denise de Souza, Rosa da Rosa Minho dos Santos, Raíne Fogliati de Carli Schardosim, Gabriela Soares Rech, Juliana de Mesquita Neto, Gabriel Pozza Estivalete, Hellen Jordan Martins Freitas, Carolina Rothmann Itaqui, Caroline Cabral Robinson e Regis Goulart Rosa Maicon Falavigna - Funcionários do Hospital Moinhos de Vento.

Figures

Figura Central
Figura Central. : Qualidade de Vida em Longo Prazo e Desfechos após Internação por COVID-19 no Brasil: Protocolo do Estudo Pós-COVID Brasil 1
Central Illustration
Central Illustration. : Long-term Health-Related Quality of Life and Outcomes after Hospitalization for COVID-19 in Brazil: Post-COVID Brazil 1 Study Protocol
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References

    1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, China. Lancet . 2020;395(10223):497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed
    1. Johns Hopkins . COVID-19 Map . Baltimore: Johns Hopkins Coronavirus Resource Center; 2022. [cited 2022 Jul 15]. Internet. https://coronavirus.jhu.edu/map.html .
    1. Brandão RA, Neto, Marchini JF, Marino LO, Alencar JCG, Lazar F, Neto, Ribeiro S, et al. Mortality and Other Outcomes of Patients with Coronavirus Disease Pneumonia Admitted to the Emergency Department: A Prospective Observational Brazilian Study. PLoS One . 2021;16(1):e0244532. doi: 10.1371/journal.pone.0244532. - DOI - PMC - PubMed
    1. World Health Organization . Coronavirus Disease (COVID-19): Post COVID-19 Condition . Geneva: WHO; 2022. [cited 2022 Jul 15]. Internet. https://www.who.int/news-room/questions-and-answers/item/coronavirus-dis... .
    1. Greenhalgh T, Knight M, A’Court C, Buxton M, Husain L. Management of Post-Acute Covid-19 in Primary Care. m3026 BMJ . 2020;370 doi: 10.1136/bmj.m3026. - DOI - PubMed

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