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. 2023 Dec 12;330(22):2157-2158.
doi: 10.1001/jama.2023.22924.

Down Syndrome in a New Era for Alzheimer Disease

Michael S Rafii  1 , Juan Fortea  2   3
Affiliations

Down Syndrome in a New Era for Alzheimer Disease

Michael S Rafii et al. JAMA. .
No abstract available

Plain language summary

This Viewpoint explains the genetic association between Alzheimer disease and Down syndrome and the negative impact of excluding people with Down syndrome from clinical trials on treatment for Alzheimer disease.

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References

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    1. Sims JR, Zimmer JA, Evans CD, et al.; TRAILBLAZER-ALZ 2 Investigators. Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial. JAMA. 2023;330(6):512–527. doi:10.1001/jama.2023.13239 - DOI - PMC - PubMed
    1. Fortea J, Zaman SH, Hartley S, Rafii MS, Head E, Carmona-Iragui M. Alzheimer’s disease associated with Down syndrome: a genetic form of dementia. Lancet Neurol. 2021;20(11):930–942. doi:10.1016/S1474-4422(21)00245-3 - DOI - PMC - PubMed
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