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. 2024 Feb;13(5):e2302087.
doi: 10.1002/adhm.202302087. Epub 2023 Dec 7.

Enhanced Antibacterial and Wound Healing Using a Metal-Organic Cluster Inspired by Artificial Photosynthesis

Long Zhu  1 , Antian Huo  1 , Yangqian Sun  2 , Yanzhao Chen  1 , Chongjiang Cao  3 , Yueqin Zheng  2 , Weiwei Guo  1
Affiliations

Enhanced Antibacterial and Wound Healing Using a Metal-Organic Cluster Inspired by Artificial Photosynthesis

Long Zhu et al. Adv Healthc Mater. 2024 Feb.

Erratum in

Abstract

Bacterial infection poses a constant threat to human health. It is crucial to develop cost-effective and multifunctional solutions to combat bacteria. In this study, inspiration has been taken from artificial photosynthesis and a hydrogel containing a photocatalytic metal-organic cluster (MOC) has been creatively formulated for wound healing and antibacterial purposes. Complete photocatalytic cycles have been achieved by combining the oxidative Ti-center and the reductive Cu-center, in which reactive oxygen species (1 O2 and ·OH) have been generated. The MOC has the capability to eliminate Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) at a concentration of 40 µg mL-1 . In addition, the hydrogel formulation (H-MOC) has been applied to wounds infected with S. aureus, resulting in improved healing efficiency. This work presents an innovative approach to utilizing photocatalytic biomaterials as non-antibiotic medications.

Keywords: antibacterial; biomaterials; photocatalytic; wound healing.

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