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1 CIRAD, UMR ASTRE, Centre for Research and surveillance on Vector-borne diseases in the Caribbean, WOAH Reference Laboratory for Heartwater, F- 97170 Petit-Bourg, Guadeloupe, France.
2 ASTRE, CIRAD, INRAE, Univ Montpellier, Montpellier, France.
1 CIRAD, UMR ASTRE, Centre for Research and surveillance on Vector-borne diseases in the Caribbean, WOAH Reference Laboratory for Heartwater, F- 97170 Petit-Bourg, Guadeloupe, France.
2 ASTRE, CIRAD, INRAE, Univ Montpellier, Montpellier, France.
Ehrlichia ruminantium is an obligate intracellular pathogenic bacterium that causes heartwater, a fatal disease of ruminants in tropical areas. Some human cases have also been reported. This globally important pathogen is primarily transmitted by ticks of the Amblyomma genus and threatens American mainland. E. ruminantium replicates within eukaryotic mammal or tick cell is a membrane-bound vacuole, where it undergoes a biphasic developmental growth cycle and differentiates from noninfectious replicative form into infectious elementary bodies. The ability of E. ruminantium to hijack host cellular processes and avoid innate immunity is a fundamental, but not yet fully understood, virulence trait of this stealth pathogen in the genomic era.
Keywords:
Ehrlichia; effectors; intracellular bacteria; outer membrane protein; pathogenesis; type IV secretion system.
The authors declare that there are no conflicts of interest.
References
Collins NE, Liebenberg J, de Villiers EP, Brayton KA, Louw E, et al. The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number. Proc Natl Acad Sci U S A. 2005;102:838–843. doi: 10.1073/pnas.0406633102.
-
DOI
-
PMC
-
PubMed
Frutos R, Viari A, Ferraz C, Morgat A, Eychenié S, et al. Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity. J Bacteriol. 2006;188:2533–2542. doi: 10.1128/JB.188.7.2533-2542.2006.
-
DOI
-
PMC
-
PubMed
Gordon JL, Oliva Chavez AS, Martinez D, Vachiery N, Meyer DF. Possible biased virulence attenuation in the Senegal strain of Ehrlichia ruminantium by ntrX gene conversion from an inverted segmental duplication. PLoS One. 2023;18:e0266234. doi: 10.1371/journal.pone.0266234.
-
DOI
-
PMC
-
PubMed
Tago D, Meyer DF. Economic game theory to model the attenuation of virulence of an obligate intracellular bacterium. Front Cell Infect Microbiol. 2016;6:86. doi: 10.3389/fcimb.2016.00086.
-
DOI
-
PMC
-
PubMed
Cangi N, Gordon JL, Bournez L, Pinarello V, Aprelon R, et al. Recombination is a major driving force of genetic diversity in the Anaplasmataceae Ehrlichia ruminantium. . Front Cell Infect Microbiol. 2016;6:111. doi: 10.3389/fcimb.2016.00111.
-
DOI
-
PMC
-
PubMed
