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Comment
. 2023 Dec 26;42(12):113474.
doi: 10.1016/j.celrep.2023.113474. Epub 2023 Nov 22.

Adhesion GPCRs in glioblastoma revisited

Tobias Langenhan  1
Affiliations
Free article
Comment

Adhesion GPCRs in glioblastoma revisited

Tobias Langenhan. Cell Rep. .
Free article

Abstract

Glioblastoma is a devastating brain malignancy that has remained intractable to modern cancer treatments. Ravn-Boess et al.1 have discovered that the adhesion G protein-coupled receptor CD97/ADGRE5 contributes to glioblastogenesis and makes for an excellent molecular surface marker flagging the tumor cells.

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Conflict of interest statement

Declaration of interests The author declares no competing interest.

Comment on

  • The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability.
    Ravn-Boess N, Roy N, Hattori T, Bready D, Donaldson H, Lawson C, Lapierre C, Korman A, Rodrick T, Liu E, Frenster JD, Stephan G, Wilcox J, Corrado AD, Cai J, Ronnen R, Wang S, Haddock S, Sabio Ortiz J, Mishkit O, Khodadadi-Jamayran A, Tsirigos A, Fenyö D, Zagzag D, Drube J, Hoffmann C, Perna F, Jones DR, Possemato R, Koide A, Koide S, Park CY, Placantonakis DG. Ravn-Boess N, et al. Cell Rep. 2023 Nov 28;42(11):113374. doi: 10.1016/j.celrep.2023.113374. Epub 2023 Nov 8. Cell Rep. 2023. PMID: 37938973 Free PMC article.

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